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from Part IV - Genome-Scale Algorithms
Published online by Cambridge University Press: 28 September 2023
This chapter shows how to perform analysis and comparison of genomes without assuming a reference genome to be available. The bidirectional BWT index turns out to be essential here, and the chapter covers a comprehensive set of techniques to manipulate this data structure. The algorithms covered include computing maximal exact/unique matches, substring kernels, matching statistics, and Jaccard similarity.
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