Skip to main content Accessibility help
×
Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-20T07:32:06.207Z Has data issue: false hasContentIssue false

2 - Recent Scientific Developments in Genetic Technologies: Implications for Future Regulation of GMOs in Developing Countries

from Part I - Risk Analysis Methodology and Decision-Making

Published online by Cambridge University Press:  05 July 2017

Ademola A. Adenle
Affiliation:
Colorado State University
E. Jane Morris
Affiliation:
University of Leeds
Denis J. Murphy
Affiliation:
University of South Wales
Get access

Summary

Transgenic organisms, also known as GMOs, were first created in for agricultural applications in the 1980s and the first GM crops were grown commercially in the early 1990s. GM crop cultivation on a wide scale started in 1996 and they are now grown on about 108 million hectares worldwide, with just over half of this area being in developing countries. These crops can be regarded as constituting the 'first generation' of GM technology that normally relies on gene transfer via Agrobacterium or biolistic methods. Since the 2010s, a new generation of technologies such as gene editing have started to be introduced for the more rapid and precise manipulation of both crop and livestock genomes. These new technologies are already leading to a reconsideration of current regulatory processes in Europe and North America that may result in less onerous procedures and easier pathways to market for such organisms. Inevitably these developments will impact on developing countries and may mark a watershed for the introduction of improved crop and livestock varieties over the coming years.
Type
Chapter
Information
Genetically Modified Organisms in Developing Countries
Risk Analysis and Governance
, pp. 13 - 25
Publisher: Cambridge University Press
Print publication year: 2017

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abbott, A. (2015). Europe's genetically edited plants stuck in legal limbo. Scientists frustrated at delay in deciding if GM regulations apply to precision gene editing. Nature 528, 319320.CrossRefGoogle Scholar
ACRE (2012). ACRE advice: New techniques used in plant breeding. [Online]. Available from www.gov.uk/government/uploads/system/uploads/attachment_data/file/239542/new-techniques-used-in-plant-breeding.pdfGoogle Scholar
Ainsworth, C. (2015). Agriculture: A new breed of edits. Nature 528, S14S15.CrossRefGoogle Scholar
Anon, . (2015a). Seeds of change. The European Union faces a fresh battle over next-generation plant-breeding techniques. Nature 520, 131132.Google Scholar
Anon, . (2015b). Crop conundrum. The EU should decide definitively whether gene-edited plants are covered by GM laws. Nature 528, 307308.Google Scholar
Armstead, I. et al. (2009). Bioinformatics in the orphan crops. Briefs in Bioinformatics 10, 645653.CrossRefGoogle ScholarPubMed
Belhaj, K. et al. (2015). Editing plant genomes with CRISPR/Cas9. Current Opinion in Biotechnology 32, 7684.CrossRefGoogle ScholarPubMed
Berg, P. (2008). Meetings that changed the world: Asilomar 1975: DNA modification secured. Nature 455, 290291.CrossRefGoogle ScholarPubMed
Bhaya, D. et al. (2011). CRISPR–Cas systems in bacteria and archaea: versatile small RNAs for adaptive defense and regulation. Annual Review of Genetics 45, 273297.CrossRefGoogle ScholarPubMed
Breyer, D. et al. (2009). Genetic modification through oligonucleotide-mediated mutagenesis. A GMO regulatory challenge? Environmental Biosafety Research 8(2), 5764.CrossRefGoogle ScholarPubMed
Cernansky, R. (2015). Super vegetables. Nature 522, 146148.CrossRefGoogle ScholarPubMed
Covshoff, S. and Hibberd, J. M. (2012). Integrating C4 photosynthesis into C3 crops to increase yield potential. Current Opinion in Biotechnology 23, 209214.CrossRefGoogle ScholarPubMed
Davis, E. (2015). Genome editing: which should I choose, TALEN or CRISPR? Technical note, GeneCopoeia Inc. [Online]. Available from www.genecopoeia.com/resource/genome-editing-talen-or-crispr/Google Scholar
Dawson, I. K. and Jaenicke, H. (2006). Underutilised plant species: the role of biotechnology. Position Paper No. 1. Colombo, Sri Lanka: International Centre for Underutilised Crops.Google Scholar
Dolgin, E. (2015). GM microbes created that can't escape the lab. Engineered bacteria kept in check with a designer diet. Nature 517, 423.CrossRefGoogle Scholar
Dong, C. et al. (2006). Oligonucleotide-directed gene repair in wheat using a transient plasmid gene repair assay system. Plant Cell Reports 25, 457465.CrossRefGoogle ScholarPubMed
Edwards, D. and Batley, J. (2010). Plant genome sequencing: applications for crop improvement. Plant Biotechnology Journal 8, 29.CrossRefGoogle ScholarPubMed
Eklöf, S. (2015). CRISPR/Cas9 mutated Arabidopsis. [Online]. Swedish Board of Agriculture, Jönköping. Available from www.umu.se/digitalAssets/171/171717_backgroud-psbs.pdf and www.upsc.se/documents/Information_on_interpretation_on_CRISPR_Cas9_mutated_plants_Final.pdfGoogle Scholar
Engdahl, W. F. (2007). Seeds of Destruction – The Hidden Agenda of Genetic Manipulation. Montreal: Global Research.Google Scholar
Erbentraut, J. and Shapiro, L. (2015). The genetic revolution could curb world hunger and pesticide use. HuffPost Science 12 December 2015.Google Scholar
EU New Techniques Working Group (2012). Final report. [Online]. Available from www.seemneliit.ee/wp-content/uploads/2011/11/esa_12.0029.pdfGoogle Scholar
FAO, IFAD & WFP (2015). The State of Food Insecurity in the World 2015. Meeting the 2015 International Hunger Targets: Taking Stock of Uneven Progress. Rome: FAO.Google Scholar
Fita, A. et al. (2015). Breeding and domesticating crops adapted to drought and salinity: a new paradigm for increasing food production. Frontiers in Plant Science 6, 978.CrossRefGoogle ScholarPubMed
Foster, T. M. et al. (2015). Two quantitative trait loci, Dw1 and Dw2, are primarily responsible for rootstock-induced dwarfing in apple. Horticulture Research 2, 15001.CrossRefGoogle ScholarPubMed
Gao, C. et al. (2014). Horizontal gene transfer in plants. Functional and Integrative Genomics 14, 2329.CrossRefGoogle ScholarPubMed
Hsu, P. D. et al. (2014). Development and applications of CRISPR–Cas9 for genome engineering. Cell 157, 12621278.CrossRefGoogle Scholar
James, C. (2015). Global status of commercialized Biotech/GM Crops: 2015. ISAAA Brief No. 49. Ithaca, NY: ISAAA. [Online]. Available from http://isaaa.org/resources/publications/briefs/51/executivesummary/default.aspGoogle Scholar
Kowalski, S. P. (2015). Golden Rice, open innovation, and sustainable gobal food security. Industrial Biotechnology 11, 8490.CrossRefGoogle Scholar
Kyndt, T. et al. (2015). The genome of cultivated sweet potato contains Agrobacterium T-DNAs with expressed genes: an example of a naturally transgenic food crop. Proceedings of the National Academy of Sciences of the USA 112, 58445849.CrossRefGoogle ScholarPubMed
Laible, G. et al. (2015). Improving livestock for agriculture – technological progress from random transgenesis to precision genome editing heralds a new era. Biotechnology Journal 10, 109120.CrossRefGoogle ScholarPubMed
Ledford, H. (2015). CRISPR, the disruptor. Nature 522, 2024.CrossRefGoogle ScholarPubMed
Lunshof, J. (2015). Regulate gene editing in wild animals. Nature 521, 127.CrossRefGoogle ScholarPubMed
Mao, Y. et al. (2013). Application of the CRISPR–Cas system for efficient genome engineering in plants. Molecular Plant 6, 20082011.CrossRefGoogle ScholarPubMed
Moghissi, A. A. et al. (2016) Golden Rice: scientific, regulatory and public information processes of a genetically modified organism. Critical Reviews in Biotechnology 36(3), 535541.Google ScholarPubMed
Murphy, D. J. (2007). Improved containment strategies in biopharming. Plant Biotechnology Journal 5, 555569.CrossRefGoogle ScholarPubMed
Murphy, D. J. (2011). Plants, Biotechnology, and Agriculture. Egham: CABI Press.CrossRefGoogle Scholar
Murphy, D. J. (2014a). Using modern plant breeding to improve the nutritional and technological qualities of oil crops. Oilseeds & Fats Crops and Lipids 21, D607, DOI: 10.1051/ocl/2014038.Google Scholar
Murphy, D. J. (2014b). The future of oil palm as a major global crop: opportunities and challenges. Journal of Oil Palm Research 26, 124.Google Scholar
Napier, J. A. et al. (2015). Transgenic plants as a sustainable, terrestrial source of fish oils. European Journal of Lipid Science and Technology 117(9), 13171324.CrossRefGoogle ScholarPubMed
Nyman, M. (2014). New techniques and the GMO-legislation, Swedish Gene Technology Advisory Board, Mistra Biotech Workshop. [Online]. Available from www.genteknik.seGoogle Scholar
Okuzaki, A. and Toriyama, K. (2004). Chimeric RNA/DNA oligonucleotide-directed gene targeting in rice. Plant Cell Reports 22, 509512.CrossRefGoogle ScholarPubMed
Oye, K. A. et al. (2014). Biotechnology. Regulating gene drives. Science 345(6197), 626628.CrossRefGoogle ScholarPubMed
Petherick, A. et al. (2015). Genome editing. Nature 528, S1S48.CrossRefGoogle ScholarPubMed
Ricroch, A. E. and Hénard-Damave, M. C. (2015). Next biotech plants: new traits, crops, developers and technologies for addressing global challenges. Critical Reviews in Biotechnology 36(4), 675690.CrossRefGoogle ScholarPubMed
Roberts, A. F. et al. (2015). Biosafety research for non-target organism risk assessment of RNAi-based GE plants. Frontiers in Plant Science 6, 958.CrossRefGoogle ScholarPubMed
Sanchez, P. A. (2015). En route to plentiful food production in Africa. Nature Plants 1, 12.CrossRefGoogle ScholarPubMed
Soucy, S. M. et al. (2015). Horizontal gene transfer: building the web of life. Nature Reviews Genetics 16, 472482.CrossRefGoogle ScholarPubMed
Telem, R. S. et al. (2013). Cisgenics – a sustainable approach for crop improvement. Current Genomics 14, 468476.CrossRefGoogle ScholarPubMed
The Arabidopsis Genome Initiative (2000). Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature 408, 795815.Google Scholar
Vanhercke, T. et al. (2013). Metabolic engineering of plant oils and waxes for use as industrial feedstocks. Plant Biotechnology Journal 11, 196210.CrossRefGoogle ScholarPubMed
Wang, Y. et al. (2014). Simultaneous editing of three homoeoalleles in hexaploid breadwheat confers heritable resistance to powdery mildew. Nature Biotechnology 32, 947951.CrossRefGoogle Scholar
Wolt, J. D. et al. (2016). The regulatory status of genome-edited crops. Plant Biotechnology Journal 14(2), 510518.CrossRefGoogle ScholarPubMed
Zhang, H. et al. (2014). The CRISPR/Cas9 system produces specific and homozygous targeted gene editing in rice in one generation. Plant Biotechnology Journal 12, 797807.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×