Skip to main content Accessibility help
×
Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-22T07:59:02.256Z Has data issue: false hasContentIssue false

Chapter 17 - Epilepsy

Published online by Cambridge University Press:  07 November 2024

David M. L. Branford
Affiliation:
Independent Pharmacy Consultant
Satheesh K. Gangadharan
Affiliation:
Leicestershire Partnership NHS Trust
Mary Barrett
Affiliation:
Leicestershire Partnership NHS Trust
Regi T. Alexander
Affiliation:
Hertfordshire Partnership University NHS Foundation Trust
Get access

Summary

Epilepsy is a common condition in the population of people with intellectual disability and for many proves intractable. Over the last 20 years a host of new antiseizure medications (antiepileptics) have been introduced to the market, and the evidence base to support their use in people with intellectual disability is reviewed. This will aim to cover new treatment approaches such as cannabinoid preparations succinctly.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2024

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Resource Documents

Harden, C, Tomson, T, Gloss, D, et al. Practice guideline summary: Sudden unexpected death in epilepsy incidence rates and risk factors: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology. 2017 Apr 25;88(17):1674-1680. https://doi.org/10.1212/WNL.0000000000003685. Erratum in: Neurology. 2019 Nov 26;93(22):982. Erratum in: Neurology. 2020 Mar 3;94(9):414. PMID: 28438841.CrossRefGoogle Scholar
National Institute for Health and Care Excellence (NICE), Clinical Guidelines (NG217). Epilepsies in children, young people and adults. Apr 2022. www.nice.org.uk/guidance/ng217.Google Scholar
Scottish Intercollegiate Guidelines Network (SIGN). Diagnosis and management of epilepsy in adults. Edinburgh: SIGN; 2015. (SIGN publication no. 143). May 2015 Rev. Sep 2018. www.sign.ac.uk.Google Scholar

References

Branford, D., & Shankar, R. (2022). Antidepressant prescribing for adult people with an intellectual disability living in England. The British Journal of Psychiatry: The Journal of Mental Science, 221(2), 488–93. https://doi.org/10.1192/bjp.2022.34.CrossRefGoogle ScholarPubMed
Branford, D., Sun, J. J., & Shankar, R. (2023). Antiseizure medications prescribing for behavioural and psychiatric concerns in adults with an intellectual disability living in England. The British Journal of Psychiatry, 22(5), 191–5. http://doi.org/10.1192/bjp.2022.182.Google Scholar
Branford, D., Sun, J. J., Burrows, L & Shankar, R. (2023). Patterns of anti-seizure medications prescribing in people with intellectual disability and epilepsy: a narrative review and analysis. The British Journal of Clinical Pharmacology, 89(7), 2028–38.CrossRefGoogle Scholar
Fisher, R. S., Acevedo, C., Arzimanoglou, A., et al. (2014). ILAE official report: A practical clinical definition of epilepsy. Epilepsia, 55(4), 475–82.CrossRefGoogle ScholarPubMed
Jackson, C. F., Makin, S. M., Marson, A. G., & Kerr, M. (2015). Pharmacological interventions for epilepsy in people with intellectual disabilities. Cochrane Database of Systematic Reviews, 9, CD005399. https://doi.org/10.1002/14651858.CD005399.pub3.Google Scholar
Noachtar, S., & Peters, A. S. (2009. Semiology of epileptic seizures: A critical review. Epilepsy & Behavior. May 1; 15(1), 29.CrossRefGoogle ScholarPubMed
O’Dwyer, M., Peklar, J., Mulryan, N., et al. (2018). Prevalence and patterns of anti‐epileptic medication prescribing in the treatment of epilepsy in older adults with intellectual disabilities. Journal of Intellectual Disability Research. Mar; 62(3), 245–61.Google ScholarPubMed
Scheffer, I. E., Berkovic, S., Capovilla, G., et al. (2017). ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology. Epilepsia. Apr; 58(4), 512–21.CrossRefGoogle Scholar
Sun, J. J., Perera, B., Henley, W., et al. (2022). Epilepsy related multimorbidity, polypharmacy and risks in adults with intellectual disabilities: A national study [published correction appears in J Neurol. 2022 Mar 5]. Journal of Neurology 269(5), 2750–60. https://doi.org/10.1007/s00415-021-10938-3.Google ScholarPubMed
Sun, J. J., Watkins, L., Henley, W., et al. (2023). Mortality risk in adults with intellectual disabilities and epilepsy: An England and Wales case-control study. Journal of Neurology, 270, 3527–36. https://doi.org/10.1007/s00415-023-11701-6.CrossRefGoogle ScholarPubMed
Tittensor, P., Tittensor, S., Chisanga, E., et al. (2021). UK framework for basic epilepsy training and oromucosal midazolam administration. Epilepsy & Behavior, 122, 108180. https://doi.org/10.1016/j.yebeh.2021.108180.CrossRefGoogle ScholarPubMed
Watkins, L., Shankar, R., & Sander, J. W. (2018). Identifying and mitigating Sudden Unexpected Death in Epilepsy (SUDEP) risk factors. Expert Reviews in Neurotherapy, 18(4), 265–74. https://doi.org/10.1080/14737175.2018.1439738.Google ScholarPubMed
Watkins, L. & Shankar, R. (2018). Reducing the risk of sudden unexpected death in epilepsy (SUDEP). Current Treatment Options in Neurology, 20(10), 40. https://doi.org/10.1007/s11940-018-0527-0.CrossRefGoogle ScholarPubMed
Watkins, L. V., Linehan, C., Brandt, C., et al. (2022). Epilepsy in adults with neurodevelopmental disability: What every neurologist should know. Epileptic Disorders. Feb; 24(1), 925.CrossRefGoogle ScholarPubMed
Watkins, L., O’Dwyer, M., Kerr, M., et al. (2020). Quality improvement in the management of people with epilepsy and intellectual disability: The development of clinical guidance. Expert Opinion on Pharmacotherapy, 21(2),173–81.CrossRefGoogle ScholarPubMed
Young, C., Shankar, R., Palmer, J., et al. (2015). Does intellectual disability increase sudden unexpected death in epilepsy (SUDEP) risk? Seizure, 25, 112–16. https://doi.org/10.1016/j.seizure.2014.10.001.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×