Book contents
- Fetal Therapy
- Fetal Therapy
- Copyright page
- Dedication
- Contents
- Contributors
- Foreword
- Section 1: General Principles
- Section 2: Fetal Disease: Pathogenesis and Treatment
- Red Cell Alloimmunization
- Structural Heart Disease in the Fetus
- Fetal Dysrhythmias
- Manipulation of Fetal Amniotic Fluid Volume
- Fetal Infections
- Fetal Growth and Well-being
- Preterm Birth of the Singleton and Multiple Pregnancy
- Complications of Monochorionic Multiple Pregnancy: Twin-to-Twin Transfusion Syndrome
- Complications of Monochorionic Multiple Pregnancy: Fetal Growth Restriction in Monochorionic Twins
- Complications of Monochorionic Multiple Pregnancy: Twin Reversed Arterial Perfusion Sequence
- Complications of Monochorionic Multiple Pregnancy: Multifetal Reduction in Multiple Pregnancy
- Fetal Urinary Tract Obstruction
- Pleural Effusion and Pulmonary Pathology
- Surgical Correction of Neural Tube Anomalies
- Fetal Tumors
- Congenital Diaphragmatic Hernia
- Fetal Stem Cell Transplantation
- Chapter 49 Stem Cell Transplantation: Clinical Potential in Treating Fetal Genetic Disease
- Chapter 50 Strategies to Repair Defects in the Fetal Membrane
- Chapter 51 Tissue Engineering and the Fetus
- Gene Therapy
- Section III: The Future
- Index
- References
Chapter 49 - Stem Cell Transplantation: Clinical Potential in Treating Fetal Genetic Disease
from Fetal Stem Cell Transplantation
Published online by Cambridge University Press: 21 October 2019
- Fetal Therapy
- Fetal Therapy
- Copyright page
- Dedication
- Contents
- Contributors
- Foreword
- Section 1: General Principles
- Section 2: Fetal Disease: Pathogenesis and Treatment
- Red Cell Alloimmunization
- Structural Heart Disease in the Fetus
- Fetal Dysrhythmias
- Manipulation of Fetal Amniotic Fluid Volume
- Fetal Infections
- Fetal Growth and Well-being
- Preterm Birth of the Singleton and Multiple Pregnancy
- Complications of Monochorionic Multiple Pregnancy: Twin-to-Twin Transfusion Syndrome
- Complications of Monochorionic Multiple Pregnancy: Fetal Growth Restriction in Monochorionic Twins
- Complications of Monochorionic Multiple Pregnancy: Twin Reversed Arterial Perfusion Sequence
- Complications of Monochorionic Multiple Pregnancy: Multifetal Reduction in Multiple Pregnancy
- Fetal Urinary Tract Obstruction
- Pleural Effusion and Pulmonary Pathology
- Surgical Correction of Neural Tube Anomalies
- Fetal Tumors
- Congenital Diaphragmatic Hernia
- Fetal Stem Cell Transplantation
- Chapter 49 Stem Cell Transplantation: Clinical Potential in Treating Fetal Genetic Disease
- Chapter 50 Strategies to Repair Defects in the Fetal Membrane
- Chapter 51 Tissue Engineering and the Fetus
- Gene Therapy
- Section III: The Future
- Index
- References
Summary
Inherited severe genetic diseases are rare but devastating disorders associated with vast morbidity and mortality. Currently there is no cure for many of these diseases, but merely pharmacological therapies replacing the missing gene product or inhibiting the progressing pathology of the disease. Stem cell transplantation has the possibility to restore the defect permanently and hematopoietic stem cell transplantation (HSCT) is today used postnatally to cure sickle-cell disease, severe combined immunodeficiency (SCID), and other immune disorders [1, 2]. However, the pathology is progressing with sustained morbidity during fetal life and the disease may already be manifested at birth.
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- Chapter
- Information
- Fetal TherapyScientific Basis and Critical Appraisal of Clinical Benefits, pp. 512 - 519Publisher: Cambridge University PressPrint publication year: 2020