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Chapter 17 - Fetal Supraventricular Tachyarrhythmias: Pharmacokinetics, Modes of Action, and Results of Anti-Arrhythmic Drug Therapy

from Fetal Dysrhythmias

Published online by Cambridge University Press:  21 October 2019

By
Edgar Jaeggi  and
Nico A. Blom
Edited by
Mark D. Kilby ,
Anthony Johnson  and
Dick Oepkes
Mark D. Kilby
Affiliation:
University of Birmingham
Anthony Johnson
Affiliation:
University of Texas Medical School at Houston
Dick Oepkes
Affiliation:
Leids Universitair Medisch Centrum
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Summary

Supraventricular tachycardia (SVT) belongs to the common cardiac causes of fetal heart failure and perinatal death [1]. With the arrival of ultrasound imaging to non-invasively detect cardiac anomalies before birth, the fetus has increasingly become the target of intended prenatal treatment. This includes the off-label administration of pharmaceutical agents via the maternal circulation or directly into the fetus to treat SVT. As anti-arrhythmic drugs act on one or several ion channels, the autonomous system, or both, we will start with an overview of the normal and abnormal electro-mechanical activation of the heart before discussing indications, modes of action, and effects of anti-arrhythmic therapy for fetal SVT.

Type
Chapter
Information
Fetal Therapy
Scientific Basis and Critical Appraisal of Clinical Benefits
 , pp. 166 - 175
Publisher: Cambridge University Press
Print publication year: 2020

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