Deciphering the Mechanisms of Developmental Heart Disease: Research from Embryonic Knockout Mice

doi:10.1017/9781108564434.015

Chapter 14 - Deciphering the Mechanisms of Developmental Heart Disease: Research from Embryonic Knockout Mice

from Structural Heart Disease in the Fetus

Published online by Cambridge University Press: 21 October 2019

Dorota Szumska ,

Robert Wilson ,

Wolfgang Weninger and

Edited by

Anthony Johnson and

Mark D. Kilby: Affiliation:
University of Birmingham
Anthony Johnson: Affiliation:
University of Texas Medical School at Houston
Dick Oepkes: Affiliation:
Leids Universitair Medisch Centrum

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Summary

Congenital heart disease (CHD) describes the abnormalities of the heart or great vessels that are present at birth and that significantly impair the function of the cardiovascular system. It is the most common birth defect, affecting up to 2% of live-born children: according to the British Heart Foundation (BHF Statistics 2018), CHD is detected in 1 out of 180 babies (excluding bicuspid aortic valve), which translates into at least 4000 affected infants in the UK per year. CHD is diagnosed in over 8% of premature births and is a leading cause of infant mortality (up to 10% of cases). Cardiac abnormalities account for more than 9% of all stillbirths after 20 weeks and up to 4% of spontaneous miscarriages before 20 weeks of pregnancy. It is estimated that in the European Union, 3000 children with heart defects die annually as ‘terminations of pregnancy for fetal anomaly’, late fetal death or early neonatal death. Some malformations, such as aortic valve anomalies, often do not manifest at birth, and as more diagnoses are being made later in life, the number of CHD cases only increases [1–3].

Type: Chapter
Information: Fetal Therapy
Scientific Basis and Critical Appraisal of Clinical Benefits
, pp. 133 - 145

DOI: https://doi.org/10.1017/9781108564434.015 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2020

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