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1 - Introduction to Fed-Batch Cultures

Published online by Cambridge University Press:  05 April 2013

Henry C. Lim  and
Hwa Sung Shin
Henry C. Lim
Affiliation:
University of California, Irvine
Hwa Sung Shin
Affiliation:
Inha University, Seoul
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Summary

A living cell of a microbial, plant, or animal source is essentially an expanding and dividing biochemical reactor in which a large number of enzyme-catalyzed biochemical reactions take place. Microbial cultures involve live microbial cells, while tissue cultures involve live plant or animal cells. These cultures can be run, as in the case of chemical and biochemical reactions, in three classical operational modes: batch, continuous, or semi-batch (semi-continuous). For the past three decades, there has been tremendous growth in the use of semi-batch reactors in the fermentation, biotechnology, chemical, and waste-treatment industries owing to increasing demands for specialty chemicals and products and to certain advantages semi-batch reactors provide. Batch and semi-batch processes are used to handle usually low-volume, high-value products such as fermentation products, including amino acids and antibiotics, recombinant DNA products, and specialty chemicals. Owing to high values of these products, profitability can be improved greatly even with marginal improvements in yield and productivity. Therefore, there are incentives to optimize batch or semi-batch reactor operations.

For a batch or semi-batch process, the objective is to maximize the profit that can be realized at the end of the run, at which time the reactor content is harvested for further processing such as separation and purification. Thus, the problem is called end point optimization as only the end, not the intermediate, results are relevant to the overall profit.

Type
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Fed-Batch Cultures
Principles and Applications of Semi-Batch Bioreactors
 , pp. 1 - 18
Publisher: Cambridge University Press
Print publication year: 2013

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