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Section 12 - Miscellaneous

Published online by Cambridge University Press:  24 November 2021

Tahir Mahmood
Affiliation:
Victoria Hospital, Kirkcaldy
Charles Savona-Ventura
Affiliation:
University of Malta, Malta
Ioannis Messinis
Affiliation:
University of Thessaly, Greece
Sambit Mukhopadhyay
Affiliation:
Norfolk & Norwich University Hospital, UK
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Print publication year: 2021

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References

References

Chen, S, Parmigiani, G. Meta-analysis of BRCA1 and BRCA2 penetrance. J Clin Oncol 2007;25:13291333.Google Scholar
Dowdy, SC, Stefanek, M, Hartmann, LC. Surgical risk reduction: prophylactic salpingo-oophorectomy and prophylactic mastectomy. Am J Obstet Gynecol 2004;191:11131123.Google Scholar
Domchek, SM, Friebel, TM, Singer, CF, et al. Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality. JAMA 2010;304:967975.Google Scholar
Manchanda, R, Abdelraheim, A, Johnson, M, et al. Outcome of risk-reducing salpingo-oophorectomy in BRCA carriers and women of unknown mutation status. BJOG 2011;118:814824.Google Scholar
Jacobs, IJ, Parmar, M, Skates, SJ, Menon, U. Ovarian cancer screening: UKCTOCS trial – authors’ reply. Lancet 2016;387:26032604.Google Scholar
Buys, SS, Partridge, E, Black, A, et al. Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial. JAMA 2011;305:22952303.Google Scholar
Bolton, KL, Chenevix-Trench, G, Goh, C, et al. Association between BRCA1 and BRCA2 mutations and survival in women with invasive epithelial ovarian cancer. JAMA 2012;307:382390.Google Scholar
Barrow, E, Robinson, L, Alduaij, W, et al. Cumulative lifetime incidence of extracolonic cancers in Lynch syndrome: a report of 121 families with proven mutations. Clin Genet 2009;75:141149.Google Scholar
Olivier, M, Goldgar, DE, Sodha, N, et al. Li–Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype. Cancer Res 2003;63:66436650.Google Scholar
Collaborative Group on Epidemiological Studies of Ovarian Cancer. Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23,257 women with ovarian cancer and 87,303 controls. Lancet 2008;371:303314.Google Scholar
Whittemore, AS, Harris, R, Itnyre, J. Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. II Invasive epithelial ovarian cancers in white women Collaborative Ovarian Cancer Group. Am J Epidemiol 1992;136:11841203.Google Scholar
Kindelberger, DW, Lee, Y, Miron, A, et al. Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship. Am J Surg Pathol 2007;31:161169.Google Scholar
Jordan, SJ, Cushing-Haugen, KL, Wicklund, KG, Doherty, JA, Rossing, MA. Breast-feeding and risk of epithelial ovarian cancer. Cancer Causes Control 2012;23:919927.Google Scholar
Sasieni, PD, Duffy, SW, Cuzick, J. Ovarian cancer screening: UKCTOCS trial. Lancet 2016;387:2602.Google Scholar
Jacobs, IJ, Menon, U, Ryan, A, et al. Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. Lancet 2016;387:945956.Google Scholar
Holmberg, L, Iversen, OE, Rudenstam, CM, et al. Increased risk of recurrence after hormone replacement therapy in breast cancer survivors. J Natl Cancer Inst 2008;100:475482.Google Scholar
Stubbs, C, Mattingly, L, Crawford, SA, et al. Do SSRIs and SNRIs reduce the frequency and/or severity of hot flashes in menopausal women? J Okla State Med Assoc 2017;110:272274.Google Scholar
Foulkes, WD, Metcalfe, K, Sun, P, et al. Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: the influence of age, grade, and histological type. Clin Cancer Res 2004;10:20292034.Google Scholar
Boyd, J, Sonoda, Y, Federici, MG, et al. Clinicopathologic features of BRCA-linked and sporadic ovarian cancer. JAMA 2000;283:22602265.Google Scholar
Watson, P, Vasen, HF, Mecklin, JP, Jarvinen, H, Lynch, HT. The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer. Am J Med 1994;96:516520.Google Scholar
Powell, CB, Kenley, E, Chen, LM, et al. Risk-reducing salpingo-oophorectomy in BRCA mutation carriers: role of serial sectioning in the detection of occult malignancy. J Clin Oncol 2005;23:127132.Google Scholar

References

Ventriglia, J, Paciolla, I, Pisano, C, et al. Immunotherapy in ovarian, endometrial and cervical cancer: state of the art and future perspectives. Cancer Treat Rev 2017;59:109116.Google Scholar
Menderes, G, Schwab, CL, Black, J, Santin, AD. The role of the immune system in ovarian cancer and implications on therapy. Expert Rev Clin Immunol 2016;12:681695.Google Scholar
Tse, BWC, Collins, A, Oehler, MK, Zippelius, A, Heinzelmann-Schwarz, VA. Antibody-based immunotherapy for ovarian cancer: where are we at? Ann Oncol 2014;15:322331.Google Scholar
Wefers, C, Lambert, LJ, Torensma, R, Hato, SV. Cellular immunotherapy in ovarian cancer: targeting the stem cell of recurrence. Gynecol Oncol 2015;137:335342.Google Scholar
Zhang, L, Conejo-Garcia, JR, Katsaros, D, et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med 2003;348:203213.Google Scholar
Hwang, WT, Adams, SF, Tahirovic, E, et al. Prognostic significance of tumor-infiltrating T-cells in ovarian cancer: a meta-analysis. Gynecol Oncol 2012;124:192198.Google Scholar
Wang, W, Zou, W, Liu, JR. Tumor-infiltrating T cells in epithelial ovarian cancer: predictors of prognosis and biological basis of immunotherapy. Gynecol Oncol 2018;151:13Google Scholar
Nelson, BH. New insights into tumor immunity revealed by the unique genetic and genomic aspects of ovarian cancer. Curr Opin Immunol 2015;33:93100.Google Scholar
Liao, JB. Immunotherapy for gynecologic cancers. Gynecol Oncol 2016;142:35.CrossRefGoogle ScholarPubMed
Bell, D, Berchuck, A, Birrer, M, et al. Integrated genomic analyses of ovarian cancer. Nature 2011;474:609615.Google Scholar
Strickland, KC, Howitt, BE, Shukla, SA, et al. Association and prognostic significance of BRCA1/2–mutation status with neoantigen load, number of tumor-infiltrating lymphocytes and expression of PD-1/PD-L1 in high grade serous ovarian cancer. Oncotarget 2016;22:1358713598.Google Scholar
Vanderstraeten, A, Tuyaerts, S, Amant, F. The immune system in the normal endometrium and implications for endometrial cancer development. J Reprod Immunol 2015;109:716.Google Scholar
Wira, CR, Fahey, JV, Ghosh, M, et al. sex hormone regulation of innate immunity in the female reproductive tract. Am J Reprod Immunol 2010;63:544565.Google Scholar
Deligdisch, L. Morphologic correlates of host response in endometrial carcinoma. Am J R Immunol 1982;2:5457.Google Scholar
Silverberg, SG, Sasano, N, Yajima, A. Endometrial carcinoma in Miyagi Prefecture, Japan: histopathologicanalysis of a cancer registry-based series and comparison with cases in American women. Cancer 1982;49:15041510.Google Scholar
de Jong, RA, Leffers, N, Boezen, HM, et al. Presence of tumor-infiltrating lymphocytes is an independent prognostic factor in type I and II endometrial cancer. Gynecol Oncol 2009;114:105110.Google Scholar
Yamagami, W, Susumu, N, Tanaka, H, et al. Immunofluorescence-detected infiltration of CD4+FOXP3+ regulatory T cells is relevant to the prognosis of patients with endometrial cancer. Int J Gynecol Cancer 2011;21:16281634.Google Scholar
Kubler, K, Ayub, TH, Weber, SK, et al. Prognostic significance of tumor-associated macrophages in endometrial adenocarcinoma. Gynecol Oncol 2014;135:176183.Google Scholar
Espinosa, I, Jose Carnicer, M, Catasus, L, et al. Myometrial invasion and lymph node metastasis in endometrioid carcinomas: tumor-associated macrophages, microvessel density, and HIF1A have a crucial role. Am J Pathol 2010;34:17081714.Google Scholar
Alexandrov, LB, Nik-Zainal, S, Wedge, DC, et al. Signatures of mutational processes in human cancer. Nature 2013;500:415421.Google Scholar
Herrero, R, Gonzalez, P, Markowitz, LE. Present status of human papillomavirus vaccine development and implementation. Lancet Oncol 2015;16:e206e216.Google Scholar
Lin, K, Roosinovich, E, Ma, B, Hung, CF, Wu, TC. Therapeutic HPV DNA vaccines. Immunol Res 2010;47:86112.Google Scholar
Lee, SJ, Yang, A, Wu, TC, Hung, CF. Immunotherapy for human papillomavirus-associated disease and cervical cancer: review of clinical and translational research. Gynecol Oncol 2016;27: e51.Google Scholar
Trimble, CL, Morrow, MP, Kraynyak, KA, et al. Safety, efficacy and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomized, double blind, placebo-controlled phase 2b trial. Lancet 2015;386:20782088.Google Scholar
van der Burg, SH, Arens, R, Ossendorp, F, et al. Vaccines for established cancer: overcoming the challenges posed by immune evasion. Nat Rev Cancer 2016;16:219233.Google Scholar
Van Poelgeest, MI, Welters, WM, van Esch, LF, et al. HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial. J Transl Med 2013;11:88.Google Scholar
Smith, JB, Stashwick, C, Powell, DJ. B7-H4 as a potential target for immunotherapy for gynecologic cancers: a closer look. Gynecol Oncol 2014;134:181189.Google Scholar
Teng, MWL, Ngiow, SF, Ribas, A, Smyth, MJ. Classifying cancers based on T-cell infiltration and PD-L1. Cancer Res 2015;75:21392145.Google Scholar
Howitt, BE, Shukla, SA, Sholl, LM, et al. Association of polymerase e–mutated and microsatellite-instable endometrial cancers with neoantigen load, number of tumor-infiltrating lymphocytes, and expression of PD-1 and PD-L1. JAMA Oncol 2015;1:13191323.Google Scholar
Herzog, TAD, Reddy, S. Gatalica ZPD- 1 and PD-L1 expression in 1599 gynecological malignancies: implications for immunotherapy. Gynecol Oncol 2015;137(Suppl. 1).Google Scholar
Le, DT, Uram, JN, Wang, H, et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med 2015;372:25092520.Google Scholar
Ott, PA, Bang, Y-J, Berton-Rigaud, D, et al. Safety and antitumor activity of pembrolizumab in advanced programmed death ligand 1-positive endometrial cancer: results from the KEYNOTE-028 study. J Clin Oncol 2017;35:25352541.Google Scholar
Menderes, G, Hicks, C, Black, JD, Schwab, CL, Santin, AD. Immune checkpoint inhibitors in gynecologic cancers with lessons learned from non-gynecologic cancers. Expert Opin Biol Ther 2016:16:9891004.Google Scholar
Bellone, S, Black, J, English, DP, et al. Solitomab, an EpCAM/CD3 bispecific antibody construct (BiTE), is highly active against primary uterine serous papillary carcinoma cell lines in vitro. Am J Obstet Gynecol 2016;214:99.e18.Google Scholar
Shaar, B, Krishnan, V, Tallapragada, S, Dorigo, O. Cell-based immunotherapy in gynecologic malignancies. Curr Opin Obstet Gynecol 2018;30:2330.Google Scholar
Stevanović, S, Draper, LM, Langhan, MM, et al. Complete regression of metastatic cervical cancer after treatment with human papillomavirus: targeted tumor-infiltrating T cells. J Clin Oncol 2015;33:15431550.Google Scholar
Haanen, JBAG, Carbonnel, F, Robert, C, et al. Management of toxicities from immunotherapy: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 2018;29(Suppl. 4):iv264iv266.Google Scholar
Hodi, FS, O’Day, SJ, McDermott, DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363:711723.Google Scholar
Weber, JS, Hodi, FS, Wolchok, JD, et al. Safety profile of nivolumab monotherapy: a pooled analysis of patients with advanced melanoma. J Clin Oncol 2017;35:785792.Google Scholar
Reck, M, Rodriguez-Abreu, D, Robinson, AG, et al. Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer. N Engl J Med 2016;375:18231833.Google Scholar

Further Reading

N.C.C. Network. Uterine neoplasms. NCCN Clinical Practice in Oncology. 2019Google Scholar
N.C.C. Network. Cervical cancer. NCCN Clinical Practice in Oncology. 2019Google Scholar
N.C.C. Network. Vulvar cancer. NCCN Clinical Practice in Oncology. 2019.Google Scholar
Colombo, N, Creutzberg, C, Amant, F, et al. ESMO–ESGO–ESTRO Consensus Conference on Endometrial Cancer: diagnosis, treatment and follow-up. Ann Oncol 2016;27:1641.Google Scholar
Schwarz, J, Beriwall, S, Esthappan, J, et al. Consensus statement for brachytherapy for the treatment of medically inoperable endometrial cancer. Brachytherapy J 2015;14:587599.CrossRefGoogle ScholarPubMed
Albuquerque, K, Hrycushko, B, Harkenrider, M, et al. Compendium of fractionation choices for gynecologic HDR brachytherapy: An American Brachytherapy Society Task Group Report. Brachytherapy J (in press).Google Scholar
ACOG. Diagnosis and treatment of cervical carcinomas. Int J Gynaecol Obstet 2002;78:7991.Google Scholar
Hansen, EC, Roach, M II. Handbook of Evidence-Based Radiation Oncology. New York: Springer.Google Scholar

References

Nout, RA, Smit, VT, Putter, H, et al. Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial. Lancet 2010;375:816823.Google Scholar
Creutzberg, CL, van Putten, WL, Koper, PC, et al. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group Post Operative Radiation Therapy in Endometrial Carcinoma. Lancet 2000;355:14041411.Google Scholar
Writing Committee on Behalf of the ASTEC Study Group. Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study. Lancet 2009;373:125-136.Google Scholar
de Boer, SM, Powell, ME, Mileshkin, L., et al. Toxicity and quality of life after adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): an open-label, multicentre, randomised, phase 3 trial. Lancet Oncol 2016;17:11141126Google Scholar
N.C.C. Network. Uterine neoplasms. NCCN Clinical Practice in Oncology. 2019.Google Scholar
Colombo, N, Creutzberg, C, Amant, F., et al. ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: diagnosis, treatment and follow-up. Ann Oncol 27;2016:1641Google Scholar
Reichardt, P. The treatment of uterine sarcomas. Ann Oncol 2012;23(Suppl. 10):x151x157.Google Scholar
Moore, DH, Thomas, GM, Montana, GS, et al. Preoperative chemoradiation for advanced vulvar cancer: a phase II study of the Gynecologic Oncology Group. Int J Radiat Oncol Biol Phys 1998;42:7985.Google Scholar
Moore, DH, Ali, S, Koh, W-J, et al. A phase II trial of radiation therapy and weekly cisplatin chemotherapy for the treatment of locally-advanced squamous cell carcinoma of the vulva: a gynecologic oncology group study. Gynecol Oncol 2012;124:529533.Google Scholar

References

Royal College of Obstetricians and Gynaecologists. Understanding audit. Clinical Governance Advice No. 5. 2003.Google Scholar
National Institute of Health and Clinical Excellence. Principles for Best Practice in Clinical Audit. Oxon: Radcliffe Medical Press, 2002.Google Scholar
National Institute of Health Research. Research toolkit, developed and tested by North Thames DeNDRoN.Google Scholar
Shaw, CS. Standards of better health: fit for purpose? BMJ 2004;329. doi:10.1136/bmj.329.7477.1250Google Scholar
Royal College of Obstetricians and Gynaecologists. Improving patient safety: risk management for maternity and gynaecology. Clinical Governance Advice No.2. 2009.Google Scholar
Mahmood, T, Arulkumaran, S, Owen, P, Dhillon, C. Models of Care in Maternity Services. London: RCOG Press, 2010.Google Scholar
McSherry, R, Pearce, P. Clinical Governance: A Guide to Implementation for Healthcare Professionals, 2nd edition. Oxford: Wiley-Blackwell, 2007.Google Scholar
Gottwald, M, Lansdown, G. Clinical Governance: Improving the Quality of Healthcare for Patients and Service Users. Milton Keynes: Open University Press, 2014.Google Scholar

References

De Muth, JE. Overview of biostatistics used in clinical research. Am J Health Syst Pharm 2009;66:7081.Google Scholar
Sacha, V, Panagiotakos, DB. Insights in hypothesis testing and making. Open Cardiovasc Med J 2016;10:196200.Google Scholar
Hon, CY, Danyluk, Q, Bryce, E et al. Comparison of qualitative and quantitative fit-testing results for three commonly used respirators in the healthcare sector. J Occup Environ Hyg 2016;14:175179.Google Scholar
Li, Z, Heng, J, Yan, J, et al. Integrated analysis of gene expression and methylation profiles of 48 candidate genes in breast cancer patients. Breast Cancer Res Treat 2016;160:371383.Google Scholar
Messinis, IE, Templeton, AA. Effects of supraphysiological concentrations of progesterone on the characteristics of the oestradiol-induced gonadotrophin surge in women. J Reprod Fertil 1990;88:513519.Google Scholar
Cohen, AM, Stavri, PZ, Hersh, WR. A categorization and analysis of the criticisms of evidence-based medicine. Int J Med Inform 2004;73:3543.Google Scholar
Spilker, B. Guide to Clinical Studies and Developing Protocols. New York: Raven Press, 1984.Google Scholar
Humaidan, P, Chin, W, Rogoff, D, et al. Efficacy and safety of follitropin alfa/lutropin alfa in ART: a randomized controlled trial in poor ovarian responders. Hum Reprod 2017;32:544555.Google Scholar
Lancaster, GA, Dodd, S, Williamson, PR. Design and analysis of pilot studies: recommendations for good practice. J Eval Clin Pract 2004;10:307312.Google Scholar
Baker, SG, Kramer, BS. The transitive fallacy for randomized trials: if A bests B and B bests C in separate trials, is A better than C? BMC Med Res Methodol 2002;13:213.Google Scholar
Olsson, H, Bladström, A, Ingvar, C, Möller, TR. A population-based cohort study of HRT use and breast cancer in southern Sweden. Br J Cancer 2001;85:674677.Google Scholar
Whiting, P, Westwood, M, Burke, M, Sterne, J, Glanville, J. Systematic reviews of test accuracy should search a range of databases to identify primary studies. J Clin Epidemiol 2008;61:357364.Google Scholar
Hartling, L, Featherstone, R, Nuspl, M, et al. The contribution of databases to the results of systematic reviews: a cross-sectional study. BMC Med Res Methodol 2016;16:127.Google Scholar
Royle, P, Milne, R. Literature searching for randomized controlled trials used in Cochrane reviews: rapid versus exhaustive searches. Int J Technol Assess Health Care 2003;19:591603.Google Scholar
Mochtar, MH, Danhof, NA, Ayeleke, RO, Van der Veen, F, van Wely, M. Recombinant luteinizing hormone (rLH) and recombinant follicle stimulating hormone (rFSH) for ovarian stimulation in IVF/ICSI cycles. Cochrane Database Syst Rev 2017;5:CD005070.Google Scholar
Resnik, DB. What is ethics in research & why is it important? 2015. Available at: www.niehs.nih.gov/research/resources/bioethics/whatis/index.cfm.Google Scholar
Resnik, DB, Zubin Master, Z. Policies and initiatives aimed at addressing research misconduct in high-income countries. PLoS Med 2013;10:e1001406.Google Scholar

References

Union Européenne des Médecins Spécialistes. European training requirements in obstetrics and gynaecology. Available at: www.uems.eu/areas-of-expertise/postgraduate-training/european-standards-in-medical-training.Google Scholar
ten Cate, O. Entrustability of professional activities and competence-based training. Med Educ 2005;39:11761177.Google Scholar
Kneebone, R, Nestel, D, Bello, F. Learning in a simulated environment. In: A Practical Guide for Medical Teachers. London: Elsevier, 2017, pp. 92100.Google Scholar
ten Cate, O, Billett, S. Competency-based medical education: origins, perspectives and potentialities. Med Educ 2014;48:325332.Google Scholar
Halsted, WS. The training of a surgeon. Bull Johns Hopkins Hosp 1904;15:267275.Google Scholar
Ericcson, KA, Krampe, AT, Tesch-Römer, C. The role of deliberate practice in the acquisition of expert performance. Psych Rev 1993;100:363406.Google Scholar
Ericcson, KA, Lehman, AC. Expert and exceptional performance: evidence of maximal adaptation to task constraints. Annu Rev Psychol 1996;47:273305.Google Scholar
Sawyer, T, White, M, Zaveri, P, et al. Learn, see, practice, prove, do, maintain: an evidence-based pedagogical framework for procedural skill training in medicine. Acad Med 2015;90:10251033.Google Scholar
Ayres-de-Campos, D, Deering, S, Siassakos, D. Sustaining simulation training programmes: experience from maternity care. BJOG 2011;118(Suppl. 3):2226.Google Scholar
Burden, C, Oestergaard, J, Larsen, CR. Integration of laparoscopic virtual-reality simulation into gynaecology training. BJOG 2011;118(Suppl. 3):510.Google Scholar

References

Scheele, F, Teunissen, P, van Luijk, S, et al. Introducing competency based postgraduate medical education in the Netherlands. Med Teach 2008;30:248253.Google Scholar
Frank, JR, Snell, LS, Ten Cate, O, et al. Competency-based medical education: theory to practice. Med Teach 2010;32:638645.Google Scholar
Scheele, F, Novak, Z, Vetter, K, Caccia, N, Goverde, A. Obstetrics and gynaecology training in Europe needs a next step. Eur J Obstet Gynecol Reprod Biol 2014;180:130132Google Scholar
van der Aa, JE, Goverde, AJ, Teunissen, PW, Scheele, F. Paving the road for a European postgraduate training curriculum. Eur J Obstet Gynecol Reprod Biol 2016;203:229231.Google Scholar
Frenk, J, Chen, L, Bhutta, ZA, et al. Health professionals for a new century: transforming education to strengthen health systems in an interdependent world. Lancet 2010;376:19231958.Google Scholar
Van der Aa, JE, Goverde, AJ, Scheele, F. Improving the training of the future gynaecologist: development of a European curriculum in Obstetrics and Gynaecology (EBCOG-PACT). Facts Views Vis Obgyn 2018;10:12.Google Scholar
Scheele, F, Van der Aa, JE, Goverde, AJ. EBCOG PACT: European curriculum for training in obstetrics and gynaecology. Available at: www.uems.eu/areas-of-expertise/postgraduate-training/european-standards-in-medical-training.Google Scholar
van der Aa, JE, Tancredi, A, Goverde, AJ, et al. What European gynaecologists need to master: consensus on medical expertise outcomes of pan-European postgraduate training in obstetrics & gynaecology. Eur J Obstet Gynecol Reprod Biol 2017;216:143152.Google Scholar
Frank, JR, Danoff, D. The CanMEDS initiative: implementing an outcomes-based framework of physician competencies. Med Teach 2007;29:642647.Google Scholar
Teunissen, P, Scheele, F, Scherpbier, A, et al. How residents learn: qualitative evidence for the pivotal role of clinical activities. Med Educ 2007;41:763770.Google Scholar
Campo, R, Wattiez, A, Tanos, V, et al. Gynaecological endoscopic surgical education and assessment: a diploma programme in gynaecological endoscopic surgery. Gynecol Surg 2016;13:133137.Google Scholar
Cook, D, Garside, S, Levinson, A, et al. What do we mean by web-based learning? A systematic review of the variability of interventions. Med Educ 2010;44:765–745.Google Scholar
Sørensen, JL, van der Vleuten, C, Rosthøj, S, et al. Simulation-based multiprofessional obstetric anaesthesia training conducted in situ versus off-site leads to similar individual and team outcomes: a randomised educational trial. BMJ Open 2015:6;5.Google Scholar
Kare, L, Sigbjorn, H. Excavating the origins of the learning pyramid myths. Cogent Educ 2018;5:10.Google Scholar
Visser, CLF, Ket, JCF, Croiset, G, Kusurkar, RA. Perceptions of residents, medical and nursing students about interprofessional education: a systematic review of the quantitative and qualitative literature. BMC Med Educ 2017;17:77.Google Scholar
Kolb, DA. Experiential Learning; Experience as the Source of Learning and Development. Harlow: Pearson Education, 2014.Google Scholar
Hattie, J, Timperley, H. The power of feedback. Rev Educ Res 2007;77:81112.Google Scholar
Wass, R, Golding, C. Sharpening a tool for teaching: the zone of proximal development. Teaching Higher Educ 2014:19;671684.Google Scholar
Van der Vleuten, C, Schuwirth, L, Scheele, F, Driessen, EW, Hodges, B. The assessment of professional competence: building blocks for theory development. Best Pract Res Clin Obstet Gynaecol 2010;24:703719.Google Scholar
Driessen, E, van Tartwijk, J, van der Vleuten, C, Wass, V. Portfolios in medical education: why do they meet with mixed success? A systematic review. Med Educ 2007;41:12241233.Google Scholar
ten Cate, O, Scheele, F. Competency-based postgraduate training: can we bridge the gap between theory and clinical practice? Acad Med 2007;82:542547.Google Scholar
Dijksterhuis, MG, Schuwirth, LW, Braat, DD, Teunissen, PW, Scheele, F. A qualitative study on trainees’ and supervisors’ perceptions of assessment for learning in postgraduate medical education. Med Teach 2013;35:e1396e1402.Google Scholar
Van der Vleuten, C, Driessen, E. What would happen to education if we take education evidence seriously? PME 2014:3,222232.Google Scholar
Barnett, R. Improving Higher Education: Total Quality Care. Bristol: Open University Press, 1992.Google Scholar
Boor, K, Van Der Vleuten, C, Teunissen, P, et al. Development and analysis of D-RECT, an instrument measuring residents’ learning climate. Med Teach 2011;33:820827.Google Scholar
Lombarts, K, Heineman, M, Arah, O. Good clinical teachers likely to be specialist role models: results from a multicenter cross-sectional survey. PLoS One 2010;5:e15202.Google Scholar
Deci, E, Olafsen, A, Ryan, R. Self-determination theory in work organizations: the state of a science. Annu Rev Organ Psychol Organ Behav 2017;4:1943.Google Scholar
Grol, R, Grimshaw, J. From best evidence to best practice: effective implementation of change in patients’ care. Lancet 2003;362:12251230.Google Scholar
Gale, R, Grant, J. Managing change in a medical context: guidelines for action. Med Teach 1997;19:239249.Google Scholar
Maravelias, C. Post-bureaucracy: control through professional freedom. J Organ Change Manag 2003;16:547566.Google Scholar
Hodges, B, Kuper, A. Theory and practice in the design and conduct of graduate medical education. Acad Med 2012;87:2533.Google Scholar

References

Kent, HL. Epidemiology of vaginitis. Am J Obstet Gynecol 1991;165:11681176Google Scholar
Anderson, MR, Klink, K, Cohrssen, A. Evaluation of vaginal complaints. JAMA 2004;291:13681379.Google Scholar
Simonetta, C, Burns, EK, Guo, MA. Vulva dermatoses: a review and update. MolMo Med 2015;112:301307.Google Scholar
Reichman, O, Luwisch, H, Sela, HY, Samueloff, A. Genital discomfort: yeast, trichomonas and bacterial vaginosis are only the tip of the iceberg. Eur J Obstet Gynecol Reprod Biol 2017;214:200201Google Scholar
Mills, BB. Vaginitis: beyond the basics. Obstet Gynecol Clin North Am 2017;44:159177.Google Scholar
Reichman, O, Margesson, LJ, Rasmussen, CA, Lev-Sagie, A, Sobel, JD. Algorithms for managing vulvovaginal symptoms: a practical primer. Curr Infect Dis Rep 2019. doi:10.1007/s11908-019-0693-6.Google Scholar
Dennerstein, G, Scurry, J, Brenan, J, Allen, D, Marin, MG. The Vulva and Vagina Manual. Victoria: Gynederm Publishing, 2005.Google Scholar
Kurman, RJ, Ellenson, LH, Ronnett, BM. Blaustein’s Pathology of the Female Genital Tract, 6th edition. New York: Springer.Google Scholar
Buchanan, DL, Kurita, T, Taylor, JA, et al. Role of stromal and epithelial estrogen receptors in vaginal epithelial proliferation, stratification and cornification. Endocrinology 1998;139:43454352.Google Scholar
Bennett, JE, Dolin, R, Blaser, MJ. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 8th edition. London: Churchill Livingston, 2015.Google Scholar
Reichman, O, Sobel, JD. Desquamative inflammatory vaginitis. Best Pract Res Clin Obstet Gynaecol 2014;28:10421050.Google Scholar
Sobel, JD, Reichman, O, Misra, D, Yoo, W. Prognosis and treatment of desquamative inflammatory vaginitis. Obstet Gynecol 2011;117:850855.Google Scholar
Bornstein, J, Goldstein, AT, Stockdale, CK, et al.; 2015 ISSVD, ISSWSH and IPPS consensus terminology and classification of persistent vulvar pain and vulvodynia. Obstet Gynecol 2016;127:745751.Google Scholar
De Andres, J, Sanchis-Lopez, N, Asensio-Samper, JM, et al. Vulvodynia: an evidence-based literature review and proposed treatment algorithm. Pain Pract 2016;16:204236.Google Scholar
Falsetta, ML, Foster, DC, Bonham, AD, Phipps, R. A review of the available clinical therapies for vulvodynia management and new data implicating proinflammatory mediators in pain elicitation. BJOG 2017;124:210218.Google Scholar
Sherrard, J, Wilson, J, Donders, G, Mendling, W, Jensen, JS. 2018 European (IUSTI/WHO) International Union against sexually transmitted infections (IUSTI) World Health Organisation (WHO) guideline on the management of vaginal discharge. Int J STD AIDS 2018;29:12581272.Google Scholar
Centers for Disease Control. Home page. Available at: www.cdc.gov.Google Scholar

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