Book contents
- Dispatches from the Land of Alzheimer’s
- Reviews
- Dispatches from the Land of Alzheimer’s
- Copyright page
- Dedication
- Lost in Thought
- Contents
- Acknowledgments
- Prologue
- 1 Physician Heal Thyself
- 2 Evaluating New Advances in Alzheimer’s Research
- 3 Alzheimer’s Dementia or Alzheimer’s Disease
- 4 The First Patient with Alzheimer’s Disease
- 5 Kidnapped in Kinshasa
- 6 Smell, Disgust, and Alzheimer’s
- 7 Apolipoprotein-4 (APOE-4)
- 8 Lost in the Fog of Alzheimer’s
- 9 My Father’s “Stuff”
- 10 Face Blindness during a Pandemic
- 11 Biomarkers for Alzheimer’s Disease
- 12 Olfactory Impairment in Covid-19 and Alzheimer’s
- 13 Alzheimer’s Disease and Work
- 14 Crossword Controversies
- 15 Can Loneliness Increase Risk for Dementia?
- 16 Excessive Laxative Use and Dementia
- 17 Dog Dementia (Canine Cognitive Dysfunction)
- 18 The Possible Role of Brain Inflammation in Alzheimer’s Disease May Be More Significant in APOE-4 Carriers
- 19 Surprisingly Good News about the Acetylcholinesterase Inhibitors (Donepezil, Rivastigmine, and Galantamine)
- 20 More about the Importance of Exercise
- 21 Rolling on the River
- 22 The MIND Diet Revisited
- 23 My Photographs, Then and Now
- 24 Does Cataract Surgery Really Decrease the Risk of Dementia?
- 25 Hearing Loss, Aphasia, and Dementia
- 26 To Sleep, Perchance to Dream
- 27 The Amyloid Hypothesis Is Not Dead, but It May Be Gasping for Breath
- 28 Could Lecanemab Offer a Ray of Hope?
- 29 A Fatal Case of Multiple Brain Hemorrhages Associated with Lecanemab
- 30 Cerebral Amyloid Angiopathy (CAA)
- 31 Hitting the Sweet Spot in the Spectrum of Alzheimer’s Disease for Future Trials of Anti-Amyloid Medications
- 32 Disappointing Results of Two Human Trials of Monoclonal Antibodies in Parkinson’s Disease
- 33 Repurposing Old Drugs for Alzheimer’s Treatment
- 34 Writing While Impaired
- 35 Spreading the Word
- 36 Saying Goodbye to Lizzie G
- 37 Amyloid and Tau PET Scans of My Brain
- 38 Running on a Field of Dreams
- 39 Living in the Moment with Alzheimer’s
- Index
- Plate Section (PDF Only)
- References
31 - Hitting the Sweet Spot in the Spectrum of Alzheimer’s Disease for Future Trials of Anti-Amyloid Medications
Published online by Cambridge University Press: 19 January 2024
Book contents
- Dispatches from the Land of Alzheimer’s
- Reviews
- Dispatches from the Land of Alzheimer’s
- Copyright page
- Dedication
- Lost in Thought
- Contents
- Acknowledgments
- Prologue
- 1 Physician Heal Thyself
- 2 Evaluating New Advances in Alzheimer’s Research
- 3 Alzheimer’s Dementia or Alzheimer’s Disease
- 4 The First Patient with Alzheimer’s Disease
- 5 Kidnapped in Kinshasa
- 6 Smell, Disgust, and Alzheimer’s
- 7 Apolipoprotein-4 (APOE-4)
- 8 Lost in the Fog of Alzheimer’s
- 9 My Father’s “Stuff”
- 10 Face Blindness during a Pandemic
- 11 Biomarkers for Alzheimer’s Disease
- 12 Olfactory Impairment in Covid-19 and Alzheimer’s
- 13 Alzheimer’s Disease and Work
- 14 Crossword Controversies
- 15 Can Loneliness Increase Risk for Dementia?
- 16 Excessive Laxative Use and Dementia
- 17 Dog Dementia (Canine Cognitive Dysfunction)
- 18 The Possible Role of Brain Inflammation in Alzheimer’s Disease May Be More Significant in APOE-4 Carriers
- 19 Surprisingly Good News about the Acetylcholinesterase Inhibitors (Donepezil, Rivastigmine, and Galantamine)
- 20 More about the Importance of Exercise
- 21 Rolling on the River
- 22 The MIND Diet Revisited
- 23 My Photographs, Then and Now
- 24 Does Cataract Surgery Really Decrease the Risk of Dementia?
- 25 Hearing Loss, Aphasia, and Dementia
- 26 To Sleep, Perchance to Dream
- 27 The Amyloid Hypothesis Is Not Dead, but It May Be Gasping for Breath
- 28 Could Lecanemab Offer a Ray of Hope?
- 29 A Fatal Case of Multiple Brain Hemorrhages Associated with Lecanemab
- 30 Cerebral Amyloid Angiopathy (CAA)
- 31 Hitting the Sweet Spot in the Spectrum of Alzheimer’s Disease for Future Trials of Anti-Amyloid Medications
- 32 Disappointing Results of Two Human Trials of Monoclonal Antibodies in Parkinson’s Disease
- 33 Repurposing Old Drugs for Alzheimer’s Treatment
- 34 Writing While Impaired
- 35 Spreading the Word
- 36 Saying Goodbye to Lizzie G
- 37 Amyloid and Tau PET Scans of My Brain
- 38 Running on a Field of Dreams
- 39 Living in the Moment with Alzheimer’s
- Index
- Plate Section (PDF Only)
- References
Summary
Evidence of beta-amyloid plaques can be found in the brains of people up to 20 years prior to the onset of cognitive impairment due to Alzheimer’s disease and yet, some people with beta-amyloid plaques will never develop Alzheimer’s. Abnormal tau protein starts to appear in neurofibrillary tangles in the brain later but still at least several years before the onset of cognitive impairment. Information from amyloid and tau PET scans as well as new blood tests for beta-amyloid and tau have confirmed this timeline. A recent paper shows how it might be possible to identify research subjects who are in this narrow window, those who currently have amyloid but no tau, but who have characteristics suggesting that they will become tau-positive and cognitively impaired within five years.
- Type
- Chapter
- Information
- Dispatches from the Land of Alzheimer's , pp. 127 - 129Publisher: Cambridge University PressPrint publication year: 2024
References
Josephs, KA, Weigand, SD, Whitwell, JL. Characterizing amyloid-positive individuals with normal tau PET levels after 5 years: An ADNI study. Neurology 2022; 98: e2282–e2292. https://doi.org/10.1212/WNL.0000000000200287; Epub 2022 Mar 21. PMID: 35314506; PMCID: PMC9162162 (open access).CrossRefGoogle ScholarPubMed