Book contents
- Developmental Origins of Health and Disease
- Developmental Origins of Health and Disease
- Copyright page
- Contents
- Contributors
- Preface
- Section I Overview
- Section II Exposures Driving Long-Term DOHaD Effects
- Chapter 2 The Evolutionary Basis of DOHaD
- Chapter 3 Timing
- Chapter 4 Long-Term Effects of Food Insecurity and Undernutrition in Early Life
- Chapter 5 Short- and Long-Term Effects of Maternal Obesity and Dysglycaemia for Women and Their Children
- Chapter 6 Long-Term Effects of Prenatal Maternal Stress and Mental Health
- Chapter 7 Environmental Exposures in Early Life
- Chapter 8 Developmental Programming and the Microbiome
- Chapter 9 Exposures Driving Long-Term DOHaD Effects
- Section III Outcomes
- Section IV Mechanisms
- Section V Interventions
- Section VI Public Health and Policy Implications of Interventions
- Index
- References
Chapter 4 - Long-Term Effects of Food Insecurity and Undernutrition in Early Life
from Section II - Exposures Driving Long-Term DOHaD Effects
Published online by Cambridge University Press: 01 December 2022
Book contents
- Developmental Origins of Health and Disease
- Developmental Origins of Health and Disease
- Copyright page
- Contents
- Contributors
- Preface
- Section I Overview
- Section II Exposures Driving Long-Term DOHaD Effects
- Chapter 2 The Evolutionary Basis of DOHaD
- Chapter 3 Timing
- Chapter 4 Long-Term Effects of Food Insecurity and Undernutrition in Early Life
- Chapter 5 Short- and Long-Term Effects of Maternal Obesity and Dysglycaemia for Women and Their Children
- Chapter 6 Long-Term Effects of Prenatal Maternal Stress and Mental Health
- Chapter 7 Environmental Exposures in Early Life
- Chapter 8 Developmental Programming and the Microbiome
- Chapter 9 Exposures Driving Long-Term DOHaD Effects
- Section III Outcomes
- Section IV Mechanisms
- Section V Interventions
- Section VI Public Health and Policy Implications of Interventions
- Index
- References
Summary
The Developmental Origins of Health and Disease (DOHaD) concept supports that the environment that you are exposed to in early life significantly impacts on both short- and longer-term health. As a modifiable exposure, diet and nutrition has been a major focus of DOHaD-related research. However, much of the focus has come from well-nourished settings with a focus on ‘optimizing’ the diet in early life for the prevention of obesity and long-term chronic disease risk. Far less attention has been given to the long-term health consequences of food insecurity and nutritional deprivation in early life.
- Type
- Chapter
- Information
- Developmental Origins of Health and Disease , pp. 27 - 37Publisher: Cambridge University PressPrint publication year: 2022
References
Hanson, M., The birth and future health of DOHaD. J Dev Orig Health Dis, 2015. 6(5): pp. 434–7.Google Scholar
Collaborators, G.B.D.C.o.D., Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet, 2017. 390(10100): pp. 1151–210.Google Scholar
FAO, I., UNICEF, WFP and WHO., The State of Food Security and Nutrition in the World 2019. Safeguarding against economic slowdowns and downturns., FAO, Editor. 2019: Rome.Google Scholar
Maternal and Child Nutrition Study Group, et al., Maternal and child nutrition: building momentum for impact. Lancet, 2013. 382(9890): pp. 372–5.Google Scholar
Development Initiatives, 2018 Global Nutrition Report: Shining a light to spur action on nutrition, D. Initiatives, Editor. 2018: Bristol, UK.Google Scholar
Bailey, R.L., West, K.P., Jr., and Black, R.E., The epidemiology of global micronutrient deficiencies. Ann Nutr Metab, 2015. 66 Suppl 2: pp. 22–33.Google Scholar
in Prevention of Micronutrient Deficiencies: Tools for Policymakers and Public Health Workers, Howson, C.P., Kennedy, E.T., and Horwitz, A., Editors. 1998. National Academies Press: Washington (DC).Google Scholar
Seligman, H.K., Laraia, B.A., and Kushel, M.B., Food insecurity is associated with chronic disease among low-income NHANES participants. J Nutr, 2010. 140(2): pp. 304–10.Google Scholar
Richter, L.M., et al., Cohort profile: the consortium of health-orientated research in transitioning societies. Int J Epidemiol, 2012. 41(3): pp. 621–6.Google Scholar
Fall, C.H., et al., Association between maternal age at childbirth and child and adult outcomes in the offspring: a prospective study in five low-income and middle-income countries (COHORTS collaboration). Lancet Glob Health, 2015. 3(7): pp. e366–77.Google Scholar
Martorell, R., et al., Weight gain in the first two years of life is an important predictor of schooling outcomes in pooled analyses from five birth cohorts from low- and middle-income countries. J Nutr, 2010. 140(2): pp. 348–54.Google Scholar
Stein, A.D., et al., Growth patterns in early childhood and final attained stature: data from five birth cohorts from low- and middle-income countries. Am J Hum Biol, 2010. 22(3): pp. 353–9.Google Scholar
Victora, C.G., et al., Maternal and child undernutrition: consequences for adult health and human capital. Lancet, 2008. 371(9609): pp. 340–57.Google Scholar
Krishnaveni, G.V. and Yajnik, C.S., Developmental origins of diabetes-an Indian perspective. Eur J Clin Nutr, 2017. 71(7): pp. 865–9.Google Scholar
India State-Level Disease Burden Initiative Diabetes, C., The increasing burden of diabetes and variations among the states of India: the global burden of disease study 1990–2016. Lancet Glob Health, 2018. 6(12): pp. e1352–62.Google Scholar
Yajnik, C.S., et al., Neonatal anthropometry: the thin-fat Indian baby. The Pune maternal nutrition study. Int J Obes Relat Metab Disord, 2003. 27(2): pp. 173–80.Google Scholar
Rao, S., et al., Intake of micronutrient-rich foods in rural Indian mothers is associated with the size of their babies at birth: Pune maternal nutrition study. J Nutr, 2001. 131(4): pp. 1217–24.Google Scholar
Yajnik, C.S., et al., Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune maternal nutrition study. Diabetologia, 2008. 51(1): pp. 29–38.Google Scholar
Norris, S.A., et al., Understanding and acting on the developmental origins of health and disease in Africa would improve health across generations. Glob Health Action, 2017. 10(1): p. 1334985.Google Scholar
Moore, S.E., Using longitudinal data to understand nutrition and health interactions in rural Gambia. Ann Hum Biol, 2020. (In Press). 47(2):125–31Google Scholar
Rayco-Solon, P., Fulford, A.J., and Prentice, A.M., Differential effects of seasonality on preterm birth and intrauterine growth restriction in rural Africans. Am J Clin Nutr, 2005. 81(1): p. 134–9.Google Scholar
Moore, S.E., et al., Season of birth predicts mortality in rural Gambia. Nature, 1997. 388(6641): p. 434.Google Scholar
Moore, S.E., et al., Prenatal or early postnatal events predict infectious deaths in young adulthood in rural Africa. Int J Epidemiol, 1999. 28(6): pp. 1088–95.Google Scholar
Moore, S.E., Early life nutritional programming of health and disease in The Gambia. J Dev Orig Health Dis, 2016. 7(2): pp. 123–31.Google Scholar
Rakyan, V.K., et al., Metastable epialleles in mammals. Trends Genet, 2002. 18(7): pp. 348–51.Google Scholar
Waterland, R.A. and Michels, K.B., Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr, 2007. 27: pp. 363–88.Google Scholar
Waterland, R.A., et al., Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles. PLoS Genet, 2010. 6(12): p. e1001252.Google Scholar
Waterland, R.A. and Jirtle, R.L., Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol, 2003. 23(15): pp. 5293–300.Google Scholar
Dominguez-Salas, P., et al., DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women. Am J Clin Nutr, 2013. 97(6): pp. 1217–27.Google Scholar
Dominguez-Salas, P., et al., Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nat Commun, 2014. 5: p. 3746.Google Scholar
Stein, A.D., et al., Cohort profile: the Institute of Nutrition of Central America and Panama (INCAP) Nutrition Trial Cohort Study. Int J Epidemiol, 2008. 37(4): pp. 716–20.Google Scholar
Habicht, J.P., Martorell, R., and Rivera, J.A., Nutritional impact of supplementation in the INCAP longitudinal study: analytic strategies and inferences. J Nutr, 1995. 125(4 Suppl): pp. 1042S–1050S.Google Scholar
Martorell, R., Overview of long-term nutrition intervention studies in Guatemala, 1968–1989. Food Nutr Bull, 1993. 14: pp. 270–7.Google Scholar
Rivera, J.A., et al., Nutritional supplementation during the preschool years influences body size and composition of Guatemalan adolescents. J Nutr, 1995. 125(4 Suppl): pp. 1068S–1077S.Google Scholar
Stein, A.D., et al., Exposure to a nutrition supplementation intervention in early childhood and risk factors for cardiovascular disease in adulthood: evidence from Guatemala. Am J Epidemiol, 2006. 164(12): pp. 1160–70.Google Scholar
Hoddinott, J., et al., Effect of a nutrition intervention during early childhood on economic productivity in Guatemalan adults. Lancet, 2008. 371(9610): pp. 411–16.Google Scholar
Kinra, S., et al., Effect of integration of supplemental nutrition with public health programmes in pregnancy and early childhood on cardiovascular risk in rural Indian adolescents: long term follow-up of Hyderabad nutrition trial. BMJ, 2008. 337: p. a605.Google Scholar
Ceesay, S.M., et al., Effects on birth weight and perinatal mortality of maternal dietary supplements in rural Gambia: 5 year randomised controlled trial. BMJ, 1997. 315(7111): pp. 786–90.Google Scholar
Moore, S.E., Collinson, A.C., and Prentice, A.M., Immune function in rural Gambian children is not related to season of birth, birth size, or maternal supplementation status. Am J Clin Nutr, 2001. 74(6): pp. 840–7.Google Scholar
Hawkesworth, S., et al., Maternal protein-energy supplementation does not affect adolescent blood pressure in The Gambia. Int J Epidemiol, 2009. 38(1): pp. 119–27.Google Scholar
Hawkesworth, S., et al., Nutritional supplementation during pregnancy and offspring cardiovascular disease risk in The Gambia. Am J Clin Nutr, 2011. 94(6 Suppl): pp. 1853S–1860S.Google Scholar
Alderman, H., et al., Supplemental feeding during pregnancy compared with maternal supplementation during lactation does not affect schooling and cognitive development through late adolescence. Am J Clin Nutr, 2014. 99(1): pp. 122–9.Google Scholar
Persson, L.A., et al., Effects of prenatal micronutrient and early food supplementation on maternal hemoglobin, birth weight, and infant mortality among children in Bangladesh: the MINIMat randomized trial. JAMA, 2012. 307(19): pp. 2050–9.CrossRefGoogle Scholar
Tofail, F., et al., Effects of prenatal food and micronutrient supplementation on infant development: a randomized trial from the Maternal and Infant Nutrition Interventions, Matlab (MINIMat) study. Am J Clin Nutr, 2008. 87(3): pp. 704–11.Google Scholar
Khan, A.I., et al., Early invitation to food and/or multiple micronutrient supplementation in pregnancy does not affect body composition in offspring at 54 months: follow-up of the MINIMat randomised trial, Bangladesh. Matern Child Nutr, 2015. 11(3): pp. 385–97.Google Scholar
Hawkesworth, S., et al., Combined food and micronutrient supplements during pregnancy have limited impact on child blood pressure and kidney function in rural Bangladesh. J Nutr, 2013. 143(5): pp. 728–34.Google Scholar
Ekstrom, E.C., et al., Effects of prenatal micronutrient and early food supplementation on metabolic status of the offspring at 4.5 years of age. The MINIMat randomized trial in rural Bangladesh. Int J Epidemiol, 2016. 45(5): pp. 1656–67.Google Scholar
Belizan, J.M., et al., Long-term effect of calcium supplementation during pregnancy on the blood pressure of offspring: follow up of a randomised controlled trial. BMJ, 1997. 315(7103): pp. 281–5.Google Scholar
Hatton, D.C., et al., Gestational calcium supplementation and blood pressure in the offspring. Am J Hypertens, 2003. 16(10): pp. 801–5.Google Scholar
Hawkesworth, S., et al., Effect of maternal calcium supplementation on offspring blood pressure in 5- to 10-y-old rural Gambian children. Am J Clin Nutr, 2010. 92(4): pp. 741–7.Google Scholar
Goldberg, G.R., et al., Randomized, placebo-controlled, calcium supplementation trial in pregnant Gambian women accustomed to a low calcium intake: effects on maternal blood pressure and infant growth. Am J Clin Nutr, 2013. 98(4): pp. 972–82.Google Scholar
Hiller, J.E., et al., Calcium supplementation in pregnancy and its impact on blood pressure in children and women: follow up of a randomised controlled trial. Aust N Z J Obstet Gynaecol, 2007. 47(2): pp. 115–21.Google Scholar
Kalra, P., et al., Effect of vitamin D supplementation during pregnancy on neonatal mineral homeostasis and anthropometry of the newborn and infant. Br J Nutr, 2012. 108(6): pp. 1052–8.Google Scholar
Roth, D.E., et al., Maternal vitamin D3 supplementation during the third trimester of pregnancy: effects on infant growth in a longitudinal follow-up study in Bangladesh. J Pediatr, 2013. 163(6): pp. 1605–11 e3.Google Scholar
Goldring, S.T., et al., Prenatal vitamin d supplementation and child respiratory health: a randomised controlled trial. PLoS One, 2013. 8(6): p. e66627.Google Scholar
Darmstadt, G.L., et al., Effect of antenatal zinc supplementation on impetigo in infants in Bangladesh. Pediatr Infect Dis J, 2012. 31(4): pp. 407–9.Google Scholar
Hamadani, J.D., et al., Zinc supplementation during pregnancy and effects on mental development and behaviour of infants: a follow-up study. Lancet, 2002. 360(9329): pp. 290–4.Google Scholar
Osendarp, S.J., et al., Zinc supplementation during pregnancy and effects on growth and morbidity in low birthweight infants: a randomised placebo controlled trial. Lancet, 2001. 357(9262): pp. 1080–5.Google Scholar
Tamura, T., et al., Effect of zinc supplementation of pregnant women on the mental and psychomotor development of their children at 5 y of age. Am J Clin Nutr, 2003. 77(6): pp. 1512–6.Google Scholar
Schmidt, M.K., et al., Randomised double-blind trial of the effect of vitamin A supplementation of Indonesian pregnant women on morbidity and growth of their infants during the first year of life. Eur J Clin Nutr, 2002. 56(4): pp. 338–46.Google Scholar
Schmidt, M.K., et al., Mental and psychomotor development in Indonesian infants of mothers supplemented with vitamin A in addition to iron during pregnancy. Br J Nutr, 2004. 91(2): pp. 279–86.Google Scholar
Parsons, A.G., et al., Effect of iron supplementation during pregnancy on the behaviour of children at early school age: long-term follow-up of a randomised controlled trial. Br J Nutr, 2008. 99(5): pp. 1133–9.Google Scholar
Zhou, S.J., et al., Effect of iron supplementation during pregnancy on the intelligence quotient and behavior of children at 4 y of age: long-term follow-up of a randomized controlled trial. Am J Clin Nutr, 2006. 83(5): pp. 1112–7.Google Scholar
WHO, Recommendations on Antenatal Care for a Positive Pregnancy Experience. 2018: Geneva, Switzerland: World Health Organization.Google Scholar
WHO/UNU/UNICEF, Composition of a multi-micronutrient supplement to be used in pilot programmes among pregnany women in developing countries: report of a United Nations Children’s Fund (UNICEF), World Health Orgnanisation (WHO) and United Nations University (UNU) workshop., UNICEF, Editor. 1999: New York.Google Scholar
Keats, E.C., et al., Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev, 2019. 3: p. CD004905.Google Scholar
Smith, E.R., et al., Modifiers of the effect of maternal multiple micronutrient supplementation on stillbirth, birth outcomes, and infant mortality: a meta-analysis of individual patient data from 17 randomised trials in low-income and middle-income countries. Lancet Glob Health, 2017. 5(11): pp. e1090–e1100.Google Scholar
WHO, WHO antenatal care recommendations for a positive pregnancy experience. Nutritional interventions update: Multiple micronutrient supplements during pregnancy, World Health Organization, Editor. 2020: Geneva.Google Scholar
Devakumar, D., et al., Maternal antenatal multiple micronutrient supplementation for long-term health benefits in children: a systematic review and meta-analysis. BMC Med, 2016. 14: p. 90.Google Scholar
Potdar, R.D., et al., Improving women’s diet quality preconceptionally and during gestation: effects on birth weight and prevalence of low birth weight--a randomized controlled efficacy trial in India (Mumbai Maternal Nutrition Project). Am J Clin Nutr, 2014. 100(5): pp. 1257–68.Google Scholar
Moore, S.E., et al., A randomized trial to investigate the effects of prenatal and infant nutritional supplementation on infant immune development in rural Gambia: the ENID trial: Early Nutrition and Immune Development. BMC Pregnancy Childbirth, 2012. 12: p. 107.Google Scholar
Moore, S.E., et al., Thymic size is increased by infancy, but not pregnancy, nutritional supplementation in rural Gambian children: a randomized clinical trial. BMC Med, 2019. 17(1): p. 38.Google Scholar
Okala, S.G., et al., Impact of nutritional supplementation during pregnancy on antibody responses to diphtheria-tetanus-pertussis vaccination in infants: A randomised trial in The Gambia. PLoS Med, 2019. 16(8): p. e1002854.Google Scholar
Hawkes, C., et al., Double-duty actions: seizing programme and policy opportunities to address malnutrition in all its forms. Lancet, 2020. 395(10218): pp. 142–55.Google Scholar