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Chapter 18 - Interventions to Prevent DOHaD Effects in Infancy and Early Childhood

from Section V - Interventions

Published online by Cambridge University Press:  01 December 2022

By
Bartłomiej Mateusz Zalewski ,
Bernadeta Patro-Gołąb ,
Barbara Bożek ,
Maciej Kołodziej ,
Kathryn V. Dalrymple ,
Lucilla Poston  and
Hania Szajewska
Edited by
Lucilla Poston ,
Keith M. Godfrey ,
Peter D. Gluckman  and
Mark A. Hanson
Lucilla Poston
Affiliation:
King's College London
Keith M. Godfrey
Affiliation:
University of Southampton
Peter D. Gluckman
Affiliation:
University of Auckland
Mark A. Hanson
Affiliation:
University of Southampton
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Summary

This chapter summarizes evidence on the effects of different nutritional interventions or exposures in early childhood on later BMI, overweight/obesity and adiposity. We present findings of a 2016 systematic review of systematic reviews, updated here by a search of Ovid Medline up to May 2020. Sixty-two systematic reviews of observational and/or interventional studies were included. Some early nutritional interventions/exposures might be associated with a later risk of overweight/obesity. No strong and consistent evidence to support a long-term ‘programming effect’ on overweight/obesity was found. Breastfeeding was associated with a modest reduction of later risk of overweight and obesity up to adult life, but residual confounding should be considered. Lowering the protein content of infant formula seems to be a promising intervention to reduce later risk of overweight and obesity in children, although new studies must replicate the effects on long-term health outcomes.

Type
Chapter
Information
Developmental Origins of Health and Disease , pp. 189 - 202
Publisher: Cambridge University Press
Print publication year: 2022

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