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Chapter 13 - Developmental Programming of Ageing Induced by Poor Maternal Nutrition

Evidence from Rodent Studies

from Section III - Outcomes

Published online by Cambridge University Press:  01 December 2022

By
Elena Zambrano  and
Peter W. Nathanielsz
Edited by
Lucilla Poston ,
Keith M. Godfrey ,
Peter D. Gluckman  and
Mark A. Hanson
Lucilla Poston
Affiliation:
King's College London
Keith M. Godfrey
Affiliation:
University of Southampton
Peter D. Gluckman
Affiliation:
University of Auckland
Mark A. Hanson
Affiliation:
University of Southampton
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Summary

Developmental programming predisposes to life-course disease, impairing multi-organ function. Cumulative changes in cellular phenotype influence healthspan and lifespan. Poor maternal nutrition is a major fetal challenge programming changes in offspring phenotype. We review longitudinal studies showing that nutritional programming accelerates sexually dimorphic ageing in multiple organs. Few studies contain the necessary data over multiple life-course ages to evaluate ageing trajectories. We focus on rodent models designed to address influences of maternal nutritional programming of offspring health and evaluate their effects on functional ageing. We report age-related outcomes in offspring of low protein fed and obese, over-nourished mothers. Effects of exercise and dietary interventions are presented to elucidate mechanisms of ageing-programming interactions. We present in vitro and in vivo data on programming-ageing interaction involving the hypothalamo-pituitary-adrenal axis, metabolic, reactive oxygen species (ROS) and reproductive function. We hypothesize that glucocorticoids and ROS represent interactive molecular systems responsible for many programming-ageing interactive outcomes.

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Chapter
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Developmental Origins of Health and Disease , pp. 121 - 131
Publisher: Cambridge University Press
Print publication year: 2022

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