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Chapter 8 - Plasma exchange and IV immunoglobulin for acute demyelinating relapses

from Section 2 - Pediatric MS Course and Treatment

Published online by Cambridge University Press:  11 April 2011

By
Khurram Bashir
Edited by
Dorothée Chabas  and
Emmanuelle L. Waubant
Dorothée Chabas
Affiliation:
University of California, San Francisco
Emmanuelle L. Waubant
Affiliation:
University of California, San Francisco
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Summary

Plasma exchange involves non-selectively removing plasma components that are potentially pathogenic in immune-mediated diseases from a patient's blood. Intravenous immunoglobulin used for therapeutic purposes are pooled human immunoglobulins derived from the plasma of 10000-100000 healthy donors. The major component of intravenous immunoglobulins (IVIg) preparations is IgG; very small amounts of other immunoglobulins, immunoglobulin fragments, and other smaller plasma proteins are also present. IVIg affect several components of the immune system and have been used successfully in the treatment of several neuroimmunological disorders. IVIg therapy has been evaluated both as a treatment of acute demyelinating relapses as well as a maintenance therapy to alter the disease course in adult patients with multiple sclerosis (MS). This chapter focuses on studies pertaining to the treatment of acute relapses. Plasma exchange might be an effective and relatively well-tolerated treatment option for severe demyelinating relapses in MS patients.

Keywords

acute disseminated encephalomyelitiscentral nervous systemdemyelinating diseasesrelapsing and remitting diseaseleukodystrophiespediatric multiple sclerosis
Type
Chapter
Information
Demyelinating Disorders of the Central Nervous System in Childhood , pp. 87 - 91
Publisher: Cambridge University Press
Print publication year: 2011

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