As a case study, this chapter analyzes some concrete manifestations of coalitions of the willing, showing how the ideas that are entailed in the conceptual metaphor ‘coalition of the willing’ (Chapter 2) have materialized over time. A closer look is taken at the Proliferation Security Initiative (PSI), and other ‘sister initiatives’ like the Global Initiative to Combat Nuclear Terrorism (GICNT), as well as the bilaterally operating Container Security Initiative (CSI). It also links these global security initiatives with US national security strategy by tracing the genesis of these coalitions, the broader network structures of which they form part and in which they operate, and their connections with US governmental programmes. It questions the classical bifurcation of the bilateral and multilateral realms in today’s global governance.