The 2020 presidential campaign occurred in the midst of the first worldwide pandemic in 100 years. The pandemic engulfed the United States for the entire length of the campaign and the incumbent president was hospitalized with the virus at the height of the fall campaign. In this chapter, we show that people’s concern about the coronavirus pandemic increased significantly after Trump contracted COVID-19. Furthermore, and consistent with the citizen-centered theory of campaigns, we find that psychological predispositions, along with political and demographic characteristics, substantively and significantly predict changes in worry about the coronavirus from September to October. For instance, people high in authoritarianism and conflict avoidance become significantly more worried about the coronavirus pandemic from September to October. Finally, we show that people are more likely to consider assessments of the candidates’ competence for dealing with the coronavirus when developing overall evaluations of the candidates in October – after Trump’s COVID-19 diagnosis – compared to September.