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5 - Antitrypanosomal and Antileishmanial Targets

Published online by Cambridge University Press:  11 August 2009

Tag E. Mansour
With
Joan MacKinnon Mansour
Tag E. Mansour
Affiliation:
Stanford University, California
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Summary

The hemoflagellates of the genus Trypanosoma and of the genus Leishmania belong to the family of Trypanosomatidae. They are blood or tissue parasites that infect humans and other vertebrates. Trypanosoma brucei gambiense and T. brucei rhodesiense are the causative organisms of African trypanosomiasis (sleeping sickness), which is prevalent in central and eastern Africa. T. brucei can also infect all domestic animals. The vector of this disease is tsetse flies of the genus Glossina. Once the fly bites the mammalian host the metacyclic trypanosomes (mature stages in fly salivary glands) cause local skin “chancre” and then migrate to the lymphatic system of the host and eventually to the bloodstream. After approximately a month the parasites cross the choroid plexus into the brain and cerebrospinal fluid. The “sleeping” symptoms, such as physical depression, mental deterioration, and even coma, then appear in the host. The causative organism of American trypanosomiasis, also known as Chagas' disease, is Trypanosoma cruzi. It is present in South and Central America, especially in Brazil, Argentina, and Mexico. Vectors for transmission are members of Triatominae, insects found in Latin America. After having a blood meal from the human host the metacyclic forms of the trypanosome enter the gut of the insects and are eventually released in the insects' feces. When the feces are deposited on the skin of the host and rubbed they penetrate the skin and enter host cells where they are transformed to amastigotes, which cause chronic local inflammatory swelling.

Type
Chapter
Information
Chemotherapeutic Targets in Parasites
Contemporary Strategies
 , pp. 90 - 128
Publisher: Cambridge University Press
Print publication year: 2002

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