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Case 14: The boy whose bed was always wet: nocturnal enuresis in a child

Published online by Cambridge University Press:  09 February 2024

Jeffrey R. Strawn
Affiliation:
University of Cincinnati, Ohio
Stephen M. Stahl
Affiliation:
University of California, San Diego
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Summary

Which of the following represents a first-line evidence-based pharmacologic intervention for a child with nocturnal enuresis?

Type
Chapter
Information
Case Studies: Stahl's Essential Psychopharmacology
Children and Adolescents
, pp. 223 - 232
Publisher: Cambridge University Press
Print publication year: 2023

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References

Caldwell, P. H. Y., Sureshkumar, P., Wong, W. C. F. Tricyclic and related drugs for nocturnal enuresis in children. Cochrane Database Syst Rev 2016; 2016(1): CD002117. https://doi.org/10.1002/14651858.CD002117.pub2Google Scholar
Dossche, L., Michelet, R., de Bruyne, P., et al. Desmopressin oral lyophilisate in young children: new insights in pharmacokinetics and pharmacodynamics. Arch Dis Childhood 2021; 106: 597602. https://doi.org/10.1136/archdischild-2019-318225Google Scholar
Findling, R. L., Candler, S. A., Nasser, A. F., et al. Viloxazine in the management of CNS disorders: a historical overview and current status. CNS Drugs 2021; 35(6): 643–53. https://doi.org/10.1007/s40263-021-00825-wGoogle Scholar
Glazener, C. M. A., Evans, J. H. C. Desmopressin for nocturnal enuresis in children. Cochrane Database Syst Rev 2002; 2010(1): CD002112. https://doi.org/10.1002/14651858.CD002112Google Scholar
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Keten, T., Aslan, Y., Balci, M., et al. Comparison of the efficacy of desmopressin fast-melting formulation and enuretic alarm in the treatment of monosymptomatic nocturnal enuresis. J Pediatr Urol 2020; 16(5): P645.E1–E7. https://doi.org/10.1016/j.jpurol.2020.07.018Google Scholar
Michelet, R., Dossche, L., van Herzeele, C. An integrated paediatric population PK/PD analysis of dDAVP: how do PK differences translate to clinical outcomes? Clin Pharmacokin 2020; 59(1): 81–96. https://doi.org/10.1007/s40262-019-00798-6Google Scholar
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Rittig, S., Knudsen, U. B., Norgaard, J. P., Pedersen, E. B., Djurhuus, J. C. Abnormal diurnal rhythm of plasma vasopressin and urinary output in patients with enuresis. Am J Physiol Renal Fluid Electrolyte Physiol 1989; 256(4): F664–71. https://doi.org/10.1152/ajprenal.1989.256.4.f664Google Scholar
Shaffer, D., Costello, A. J., Hill, I. D. Control of enuresis with imipramine. Arch Dis Childhood 1968; 43(232): 665. https://doi.org/10.1136/adc.43.232.665Google Scholar
Yu, C., Garcia-Olivares, J., Candler, S., Schwabe, S., Maletic, V. New insights into the mechanism of action of viloxazine: serotonin and norepinephrine modulating properties. J Exp Pharmacol 2020; 12: 285300. https://doi.org/10.2147/JEP.S256586Google Scholar

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