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Chapter 19 - Renal Morbidity Associated with Cardiopulmonary Bypass

Published online by Cambridge University Press:  24 October 2022

Florian Falter
Affiliation:
Royal Papworth Hospital, Cambridge
Albert C. Perrino, Jr
Affiliation:
Yale University Medical Center, Connecticut
Robert A. Baker
Affiliation:
Flinders Medical Centre, Adelaide
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Summary

Acute kidney injury is the most common major complication after cardiac surgery. The incidence of cardiac surgery-associated AKI (CSA-AKI) varies between 5% to 40% and leads to dramatically worse outcomes. The incidence of CSA-AKI requiring renal replacement therapyafter coronary artery bypass grafting alone is roughly 1%. After valve surgery or combined CABG plus valve surgery the risk of requiring RRT increases to 1.7 and 3.3% respectively.Regardless of its reversibility, CSA-AKI has been associated with increased mortality and risk of developing chronic or end-stage renal disease, and consequently generating substantial cost.

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Publisher: Cambridge University Press
Print publication year: 2022

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References

Suggested Further Reading

Cheungpasitporn, W, Thongprayoon, C, Kittanamongkolchai, W et al. Comparison of renal outcomes in off-pump versus on-pump coronary artery bypass grafting: a systematic review and meta-analysis of randomized controlled trials. Nephrology. October 2015;20(10):727735.Google Scholar
Chew, STH, Hwang, NC. Acute kidney injury after cardiac surgery: a narrative review of the literature. J Cardiothorac Vasc Anesth. August 7, 2018.Google Scholar
Cole, SP. Stratification and risk reduction of perioperative acute kidney injury: an update. Anesthesiol Clin. December 2018;36(4):539551.CrossRefGoogle ScholarPubMed
Hoste, EAJ, Vandenberghe, W. Epidemiology of cardiac surgery-associated acute kidney injury. Best Pract Res Clin Anaesthesiol. September 2017;31(3):299303.CrossRefGoogle ScholarPubMed
Kim, WH, Hur, M, Park, SK et al. Pharmacological interventions for protecting renal function after cardiac surgery: a Bayesian network meta-analysis of comparative effectiveness. Anaesthesia. August 2018;73(8):10191031.CrossRefGoogle ScholarPubMed
Nadim, MK, Forni, LG, Bihorac, A et al. Cardiac and vascular surgery-associated acute kidney injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group. J Am Heart Assoc. June 1, 2018;7(11).Google Scholar
Wang, Y, Bellomo, R. Cardiac surgery-associated acute kidney injury: risk factors, pathophysiology and treatment. Nat Rev Nephrol. November 2017;13(11):697711.Google Scholar
Whiting, P, Morden, A, Tomlinson, LA et al. What are the risks and benefits of temporarily discontinuing medications to prevent acute kidney injury? A systematic review and meta-analysis. BMJ open. April 7, 2017;7(4):e012674.Google Scholar
Ranucci, M, Biagioli, B, Scolletta, S et al. Lowest hematocrit on cardiopulmonary bypass impairs the outcome in coronary surgery: nn Italian multicenter study from the National Cardioanesthesia Database. Tex Heart Inst J. 2006;33(3):300305.Google Scholar
Newland, RF, Baker, RA, Mazzone, AL et al. Perfusion downunder collaboration. rewarming temperature during cardiopulmonary bypass and acute kidney injury: a multicenter analysis. Ann Thorac Surg. May 2016;101(5):16551662.Google Scholar

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