The quantity and nutritional quality of food available to human populations undoubtedly played a major role in the adaptive processes associated with human evolution. This should have been particularly the case in that period of human history from Mesolithic times to the present when epochal changes took place in the subsistence base of many human societies. In the Near East the domestication of plants and animals began toward the end of the Mesolithic period but became fully developed in the Neolithic. This development included agriculture and pastoralism along with cultural changes associated with greater sedentism and urbanism.

Paleopathology, primarily through the study of human skeletal remains, has attempted to interpret the impact such changes have had upon human health. A recent focus has been on the transition from a hunting and gathering way of life to one associated with incipient or fully developed agriculture (e. g., Cohen and Armelagos 1984b; Cohen 1989; Meiklejohn and Zvelebil 1991). One of the questions being asked is whether greater dependence on fewer food sources increased human vulnerability to famine and malnutrition. The later transition into an increasingly sedentary urban existence in the Bronze and Iron Ages has not been as carefully studied. However, analysis of data from skeletal remains in numerous archaeological sites is providing insight into some of the effects upon nutrition that increasing human density and attendant subsistence changes have had.

In the study of prehistoric health, perhaps the least complex nutritional data comes from human remains that have been mummified. Preservation of human soft tissues occurs either naturally, as in the bogs of northern Europe and very arid areas of the world, or through cultural intervention with embalming methods. Some mummies have provided direct evidence of diet from the intestinal contents of their stomachs (e.g., Glob 1971: 42–3; Fischer 1980: 185–9; Brothwell 1986: 92). However, the most ubiquitous source of data comes from human skeletal remains where the impact of dietary factors tends to be indirect, limited, and difficult to interpret.