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2c - Questioning Current Directions in Personality Disorder Genetics: Author Rejoinder to Commentaries on Issues and New Directions in Personality Disorder Genetics

from Part I - Etiology

Published online by Cambridge University Press:  24 February 2020

By
Kerry L. Jang  and
Fiona Choi
Edited by
Carl W. Lejuez  and
Kim L. Gratz
Carl W. Lejuez
Affiliation:
University of Kansas
Kim L. Gratz
Affiliation:
University of Toledo, Ohio
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Summary

Genetic influences on personality disorder have typically been understood as a risk factor that is activated when exposed to a specific environmental influence. Given the failure to find specific genes associated with the development of personality disorder despite the high heritability of its measures the authors suggest an alternative hypothesis: the biological basis of personality as reflected in the genes is not a liability but instead a protective factor against the vagaries of the environment.

Keywords

personalitypersonality disordernull hypothesisgenetic liabilityprotective factors
Type
Chapter
Information
The Cambridge Handbook of Personality Disorders , pp. 48 - 49
Publisher: Cambridge University Press
Print publication year: 2020

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References

Allport, G. (1937). Personality: A Psychological Interpretation. New York: Holt, Rinehart & Winston.Google Scholar
Bulbena-Cabre, A., Bassir Nia, A., & Perez-Rodriguez, M. M. (2018). Current knowledge on gene–environment interactions in personality disorders: An update. Current Psychiatry Reports, 20, 74.CrossRefGoogle ScholarPubMed
Carpenter, R. W., Tomko, R. L., Trull, T. J., & Boomsma, D. I. (2013). Gene–environment studies and borderline personality disorder: A review. Current Psychiatry Reports, 15, 336.Google Scholar
Gescher, D. M., Kahl, K. G., Hillemacher, T., Frieling, H., Kuhn, J., & Frodl, T. (2018). Epigenetics in personality disorders: Today’s insights. Frontiers in Psychiatry, 9, 579.CrossRefGoogle ScholarPubMed
Jaffee, S. R., & Price, T. S. (2007). Gene–environment correlations: A review of the evidence and implications for prevention of mental illness. Molecular Psychiatry, 12, 432–442.Google Scholar
Turkheimer, E., Pettersson, E., & Horn, E. A. (2014). Phenotypic null hypothesis for the genetics of personality. Annual Review of Psychology, 65, 515–540.Google Scholar

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