A focus on care draws attention to the fact that ethical self-cultivation, even in traditions that foreground moral autonomy, relies upon relationships of dependence. The recognition of relational and ethical dependence is familiar to anthropologists and has long been central for feminist ethics. However, the enormous body of anthropological scholarship that has emerged on care over the last decade raises the question of ethical dependence anew. This chapter problematizes the concept of care. It asks: how might ‘care’ as a topic, and as engaged ethnographically, trouble some of the ways that ethical life more broadly has been conceived in the philosophical and anthropological literature? Conversely, how might attention to the ethical stakes of care trouble some of the rich ethnographic scholarship on care? The chapter draws most substantially on anthropological and philosophical scholarship in virtue ethics and in phenomenology to consider both the relational complexities of care and care’s ineffable and elusive ethical dimensions.