This chapter introduces the most significant aspects of Thucydidean interpretation in the Renaissance and Reformation. It outlines key developments in the accessibility of the text (through knowledge of Greek and through translation into Latin and other European languages). It also analyses a number of key responses to the work. These include the group centred around Philipp Melanchthon, who saw Thucydides as a source of both rhetorical and moral lessons; Calvinist readings, which enlisted Thucydides to rebut Machiavelli’s views on statecraft; Grotius, who appealed to Thucydides in formulating his theory of Just War; and Thomas Hobbes’ influential translation of the text.