Uncle Tom’s Cabin, Harriet Beecher Stowe’s antislavery novel, was a tremendous success and the source of intense polemic when it first appeared in 1852. Since then, the novel has never entirely disappeared from the scene and has remained the locus of heated discussion on the representation of race and on race relations in the United States. This chapter will attempt to trace the role Uncle Tom’s Cabin – Stowe’s novel, but also its rewritings, tie-ins, and adaptations – has played in discussions of race in the United States since the 1850s. The first part will investigate the inception of the novel, its strategies, publishing circumstances, and immediate reception. The second part will focus on the afterlife of Uncle Tom’s Cabin, both in terms of scholarly commentary and popular appropriations.