This chapter provides an overview of gender and sexuality in Byron. It situates the Byronic hero in the context of Regency understandings of masculinity and discusses Byronic sexuality in relation to the larger history of sexuality. In addition, it stresses the ways that Byron at times uses both race and disability to shape his representations of gender and sexuality. The main character of Lara provides an exemplar of the Byronic hero and is explored in terms of his ambiguity and power to draw attention to himself. Sardanapalus provides a contrasting case of a hero whose masculinity and connections to militarism prove to be self-defeating. Manfred and Don Juan reveal Byron’s interest in linking sexuality to mystery and unspeakability. In addition, The Bride of Abydos and Don Juan link sexuality to race in the figure of the African eunuch, whose behaviour is critical in protecting the hero from tyrannical rule.