The chapter assesses the General Framework for HCI research for coherence against HCI theories. The General Framework comprises concepts of discipline, general as common, general problem, particular scope, general research, general knowledge and general practices. The theories comprise extended cognitive (as external cognition, distributed cognition and ecological cognition), social (as situated action and CSCW (computer-supported cooperative work)) and miscellaneous (as ethnography, grounded, design, human values, technology as experience, critical and in-the-wild).The assessment concerns the key concepts of the HCI theories, although other concepts are also referenced. The concepts of the General Framework are assessed as generally coherent. The assessment does not constitute a validation of the General Framework. However, it does show promise for such validation. The outcome is also indicative as to the potential of the General Framework to support research that aims to develop such theories.