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19 - Androgens and DHEA in postmenopausal medicine

from Section 4 - The tool kit

Published online by Cambridge University Press:  05 July 2015

Leo Plouffe, Jr
Affiliation:
Bayer Healthcare, Wayne, New Jersey
Botros R. M. B. Rizk
Affiliation:
University of South Alabama
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Publisher: Cambridge University Press
Print publication year: 2015

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References

1.Davison, SL, Bell, R, Donath, S, et al. Androgen levels in adult females: changes with age, menopause, and oophorectomy. J Clin Endocrinol Metab 2005;90:3847–53.Google Scholar
2.Judd, HL, Judd, GE, Lucas, WE, Yen, SS. Endocrine function of the postmenopausal ovary: concentrations of androgens and estrogens in ovarian and peripheral vein blood. J Clin Endocrinol Metab 1974;39:1020–4.Google Scholar
3.Fogle, RH, Stanczk, FZ, Zhang, X, Paulson, RJ. Ovarian androgen production in postmenopausal women. J Clin Endocrinol Metab 2007;92:3040–3.Google Scholar
4.Laughlin, GA, Barrett-Connor, E, Kritz-Silverstein, D, von Muhlen, D. Hysterectomy, oophorectomy and endogenous sex hormone levels in older women: the Rancho Bernardo Study. J Clin Endocrinol Metab 2000;85:645–51.Google ScholarPubMed
5.Labrie, F, Belanger, A, Cusan, L, et al. Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Metab 1997;82:2396–402.CrossRefGoogle ScholarPubMed
6.Greenblatt, RB, Barfield, WE, Garner, JF, et al. Evaluation of an estrogen, androgen, estrogen-androgen combination, and a placebo in the treatment of the menopause. J Clin Endocrinol 1950;10:1547–58.Google Scholar
7.Bachmann, G, Bancroft, J, Braunstein, G, et al. Female androgen insufficiency: the Princeton consensus statement on definition, classification, and assessment. Fertil Steril 2002;77(4):660–5.Google Scholar
8.Weinman, ME, Bassoon, R, Davis, SR, et al. Androgen therapy in women: and Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2006;91(10):3697–710.Google Scholar
9.Abu, EO, Horner, A, Kusec, V, et al. The localization of androgen receptors in human bone. J Clin Endocrinol Metab 1997;82(10):3493–7.Google Scholar
10.Dubin, NH, Monahan, LK, Yu-Yahiro, JA, et al. Serum concentrations of steroids, parathyroid hormone, and calcitonin in postmenopausal women during the year following hip fracture: effect of location of fracture and age. J Gerontol A Biol Sci Med Sci 1999;54(9):M46773.Google Scholar
11.Cummings, SR, Browner, WS, Bauer, D, et al. Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of Osteoporotic Fractures Research Group. N Engl J Med 1998; 339(11):733–8.Google Scholar
12.Barrett-Connor, E, Young, R, Notelovitz, M, et al. A two-year, double-blind comparison of estrogen-androgen and conjugated estrogens in surgically menopausal women. Effects on bone mineral density, symptoms and lipid profiles. J Reprod Med 1999;44(12):1012–20.Google Scholar
13.Watts, NB, Notelovitz, M, Timmons, MC, et al. Comparison of oral estrogens and estrogens plus androgens on bone mineral density. Obstet Gynecol 1995;85(4):529–37.CrossRefGoogle ScholarPubMed
14.Raisz, LG, Wiita, B, Artis, A, et al. Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women. J Clin Endocrinol Metab 1996;81(1):3743.Google Scholar
15.Kenemans, P, Bundred, NJ, Foidart, JM, et al; LIBERATE Study Group. Safety and efficacy of tibolone in breast-cancer patients with vasomotor symptoms: a double-blind, randomised, non-inferiority trial. Lancet Oncol 2009;10(2):135–46.CrossRefGoogle ScholarPubMed
16.Baulieu, EE, Thomas, G, Legrain, S, et al. Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEA Study to a sociobiomedical issue. Proc Natl Acad Sci USA 2000;97(8):4279–84.CrossRefGoogle ScholarPubMed
17.Jankowski, CM, Gozansky, WS, Kittelson, JM, et al. Increases in bone mineral density in response to oral dehydroepiandrosterone replacement in older adults appear to be mediated by serum estrogens. J Clin Endocrinol Metab 2008;93(12):4767–73.Google Scholar
18.Stewart, CE, Pell, JM. Point:Counterpoint: IGF is/is not the major physiological regulator of muscle mass. Point: IGF is the major physiological regulator of muscle mass. J Appl Physiol 2010;108(6):1820–1;discussion 1823–4; author reply 1832.Google Scholar
19.Floter, A, Nathorst-Boos, J, Carlstrom, K, et al. Effects of combined estrogen/testosterone therapy on bone and body composition in oophorectomized women. Gynecol Endocrinol 2005;20(3):155–60.Google Scholar
20.Davis, SR, McCloud, P, Strauss, BJ, Burger, H. Testosterone enhances estradiol’s effects on postmenopausal bone density and sexuality. Maturitas 1995;21(3):227–36.Google Scholar
21.Basaria, S, Collins, L, Dillon, EL, et al. The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men J Gerontol A-Biol Sci Med Sci 2013;68(1):8795.Google Scholar
22.Sarrel, PM. Psychosexual effects of menopause: role of androgens. Am J Obstet Gynecol 1999;180:S31924.CrossRefGoogle ScholarPubMed
23.Santoro, N, Torrens, J, Crawford, S, et al. Correlates of circulating androgens in mid-life women: the study of women’s health across the nation. J Clin Endocrinol Metab 2005;90:4836–45.Google Scholar
24.Glaser, R, York, AE, Dimitrakakis, C. Beneficial effects of testosterone therapy in women measured by the validated Menopause Rating Scale (MRS). Maturitas 2011;68(4):355–61.Google Scholar
25.Mertens, HJ, Heineman, MJ, Koudstaal, J, et al. Androgen receptor content in human endometrium. Eur J Obstet Gynecol Reprod Biol 1996;70:1113.Google Scholar
26.Tuckerman, E, Okon, M, Tin-Chiu, L, Laird, S. Do androgens have a direct effect on endometrial function? An in vitro study. Fertil Steril 2000;74:771–9.Google Scholar
27.Maia, H, Haddad, C, Coelho, G, Casoy, J. Role of inflammation and aromatase expression in the eutopic endometrium and its relationship with the development of endometriosis. Women’s Health 2012;8(6):647–58.Google Scholar
28.Yamaki, J, Yamamoto, T, Okada, H. Aromatization of androstenedione by normal and neoplastic endometrium of the uterus. J Steroid Biochem 1985;22(1):63–6.Google Scholar
29.Legro, RS, Kunselman, AR, Miller, SA, Satyaswaroop, PG. Role of androgens in the growth of endometrial carcinoma: an in vivo animal model. Am J Obstet Gynecol 2001;184(3):303–8.CrossRefGoogle ScholarPubMed
30.Potischman, N, Hoover, RN, Brinton, LA, et al. Case-control study of endogenous steroid hormones and endometrial cancer. J Natl Cancer Inst 1996;88:1127–35.Google Scholar
31.Lukanova, A, Lundin, E, Micheli, A, et al. Circulating levels of sex steroid hormones and risk of endometrial cancer in postmenopausal women. Int J Cancer 2004;108:425–32.Google Scholar
32.Boman, K, Strang, P, Backstrom, T, Stendahl, U. The influence of progesterone and androgens on the growth of endometrial carcinoma. Cancer 1993;71:3565–9.Google Scholar
33.Hickok, L, Toomey, C, Speroff, L. A comparison of esterified estrogens with and without methyltestosterone: effects on endometrial histology and serum lipoproteins in postmenopausal women. Obstet Gynecol 1993;82:919–24.Google Scholar
34.Zang, H, Sahlin, L, Masironi, B, et al. Effects of testosterone treatment on endometrial proliferation in postmenopausal women. J Clin Endocrinol Metab 2007;92(6):2169–75.Google Scholar
35.Davis, SR, Moreau, M, Kroll, R, et al. Testosterone for low libido in postmenopausal women not taking estrogen. N Engl J Med 2008;359:2005–17.CrossRefGoogle Scholar
36.Shifren, J, Davis, SR, Moreau, M, et al. Testosterone patch for the treatment of hypoactive sexual desire disorder in naturally menopausal women: results from the INTIMATE NM1 Study. Menopause 2006;13(5):770–9.Google Scholar
37.Hickey, T, Robinson, L, Carroll, J, Tilley, W. Minireview: The androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene? Mol Endocrinol 2012; 26:1252–67.CrossRefGoogle ScholarPubMed
38.Grynberg, M, Fanchin, R, Dubost, G, et al. Histology of genital tract and breast tissue after long term testosterone administration in a female-to-male transsexual population. Reprod Biomed Online 2010;20:553–8.Google Scholar
39.Hofling, M, Hirschberg, A, Skoog, L, et al. Testosterone inhibits estrogen/progesterone-induced breast cell proliferation in postmenopausal women. Menopause 2007;14(2):183–90.Google Scholar
40.Tamimi, R, Hankinson, S, Chen, W, et al. Combined estrogen and testosterone use and risk of breast cancer in postmenopausal women. Arch Intern Med 2006;166:1483–9.CrossRefGoogle ScholarPubMed
41.Panay, N, Al-Azzawi, F, Bouchard, C, et al. Testosterone treatment of HSDD in naturally menopausal women: the ADORE study. Climacteric 2010;13:121–31.Google Scholar
42.Nachtigall, L, Casson, P, Lucas, J, et al. Safety and tolerability of testosterone patch therapy for up to 4 years in surgically menopausal women receiving oral or transdermal estrogen. Gynecol Endocrinol 2011;27(1):3948.Google Scholar
43.Key, T, Appleby, P, Barnes, I, et al. Endogenous Hormones and Breast Cancer Collaborative Group. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst 2002;94(8):606–16.Google Scholar
44.Dimitrakakis, C, Zhou, J, Wang, J, et al. A physiologic role for testosterone in limiting estrogenic stimulation of the breast. Menopause 2003;10(4):292–8.Google Scholar

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