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25 - Tele-Trials, Remote Monitoring, and Trial Technology for Alzheimer’s Disease Clinical Trials

from Section 3 - Alzheimer’s Disease Clinical Trials

Published online by Cambridge University Press:  03 March 2022

By
Rhoda Au ,
Honghuang Lin  and
Vijaya B. Kolachalama
Edited by
Jeffrey Cummings ,
Jefferson Kinney  and
Howard Fillit
Jeffrey Cummings
Affiliation:
University of Nevada, Las Vegas
Jefferson Kinney
Affiliation:
University of Nevada, Las Vegas
Howard Fillit
Affiliation:
Alzheimer’s Drug Discovery Foundation
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Summary

Digital technologies show great promise for moving clinical trials from using in-person approaches that have perpetuated long drug trial timelines, biased sampling and high costs. A review of the current state, however, reveals that technology use has been largely limited to replicating known methods and/or applied to small study samples. Full realization of the potential will require significant investment in validating digital signals into novel metrics fueled by advanced computational methods. These steps, however, will require regulatory guidance, as well as considerations regarding data security and future proofing against rapid technology obsolescence. Despite these challenges, the end-to-end virtual clinical trial is possible today.

Keywords

digital technologysmartphoneswearablessensorspassive engagementdata scienceFDA regulations
Type
Chapter
Information
Alzheimer's Disease Drug Development
Research and Development Ecosystem
 , pp. 292 - 300
Publisher: Cambridge University Press
Print publication year: 2022

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