This chapter considers a range of internal and external restrictions (individual, institutional, national, and international) on the production of knowledge, which is situated in the dominant framing discourse of global neoliberalism. Recognising forms of restrictions on knowledge relates to how academic freedom itself is constructed, invoking the proposition that certain prerequisites are necessary for the practice of academic freedom. The chapter examines how university governance and funding mechanisms can constrain academic freedom. Within the university context, it extends its consideration to the role of ethics committees, bureaucratisation of university procedures, role of students, and university environment. The role of self-censorship at the individual level and the notion of scholars’ responsibility as well as freedom are critically examined. State-level restrictions are also considered. The chapter also situates these university-level and state-level restrictions within transnational restrictions, including international law and movement across borders.