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11A - Intralipid Therapy Has a Place in Infertility Treatment

For

from Section II - IVF Add-ons

Published online by Cambridge University Press:  25 November 2021

Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
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Summary

Successful implantation depends on balanced immunological network. This fact is widely recognised, but the exact mechanism and the interaction between maternal and fetal components of this complex system are not entirely understood and ongoing research brings constant development in this area. Any imbalance to this system may lead to recurrent miscarriage and implantation failure. Increased numbers and cytotoxic activity of NK cells have been reported in women with reproductive failures and recurrent miscarriage. A number of studies reported that Intralipid infusion may modulate immune function with suppression of NK cytotoxicity and pro-inflammatory cytokine generation. Data analysing the use of intralipids in fertility is sparse; however, the existent data is encouraging. Studies have demonstrated improvement in biochemical and clinical pregnancy, implantation and baby birth rates.

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Chapter
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Publisher: Cambridge University Press
Print publication year: 2021

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References

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Mekinian, A, Cohen, J, Alijotas-Reig, J, et al. Unexplained recurrent miscarriage and recurrent implantation failure: is there a place for immunomodulation? Am J Reprod Immunol. 2016 July;76(1):828.CrossRefGoogle Scholar
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