One of the most used, but poorly defined, terms in the management of clinical depression is that of treatment-resistant depression (TRD) (McIntyre et al., 2023). It implies that persons with major depression have received a range of appropriate psychological, medical or physical treatments (at appropriate doses and for appropriate durations) but have not experienced a significant clinical response. Intrinsically, it does not require consideration as to whether those treatments provided were relevant to their age or developmental stage, clinical phenotype, interpersonal or social context, or personal illness trajectory. These broader clinical considerations often influence initial and subsequent treatment choices.

Paradigms of governance are defined in part by paradigms of contestation—stockpiles of culturally legible tactics for contesting power. This article analyzes the growing use of hard-block and mutual aid tactics in Metulia (sometimes called Victoria, B.C.) as exemplars that suggest liberal paradigms of contestation may be becoming less rigid. Drawing on Robert Cover and Charles Tilly, I argue that the present conjuncture is not, as many analyses suggest, merely a tipping point between one paradigm and the next. Rather, it is a creative moment of experimentation and indeterminacy defined by multiple crises, multiple emergences, and their unpredictable interactions.

The rise in the number of automated robotic kitchens accelerated the need for advanced food handling system, emphasizing food analysis including ingredient classification pose recognition and assembling strategy. Selecting the optimal piece from a pile of similarly shaped food items is a challenge to automated meal assembling system. To address this, we present a constructive assembling algorithm, introducing a unique approach for food pose detection–Fast Image to Pose Detection (FI2PD), and a closed-loop packing strategy. Powered by a convolutional neural network (CNN) and a pose retrieval model, FI2PD is adept at constructing a 6D pose from only RGB images. The method employs a coarse-to-fine approach, leveraging the CNN to pinpoint object orientation and position, alongside a pose retrieval process for target selection and 6D pose derivation. Our closed-loop packing strategy, aided by the Item Arrangement Verifier, ensures precise arrangement and system robustness. Additionally, we introduce our FdIngred328 dataset of nine food categories ranging from fake foods to real foods, and the automatically generated data based on synthetic techniques. The performance of our method for object recognition and pose detection has been demonstrated to achieve a success rate of 97.9%. Impressively, the integration of a closed-loop strategy into our meal-assembly process resulted in a notable success rate of 90%, outperforming the results of systems lacking the closed-loop mechanism.

Questions concerning border closures during pandemics often focus on international borders or rights-based considerations. Closures of internal borders in federal countries, such as Canada, raise independent concerns regarding who can close internal borders when. Those questions are not exhausted by rights-based considerations and cannot be resolved using brute empirical measures. They instead implicate the nature and ends of federalism. This text uses the case of internal border restrictions in Canada during COVID-19 to explore whether the kinds of closures that took place there can be justified on federalism grounds. It argues that the case for provinces being able to unilaterally enact interprovincial border closures in federal countries, as observed in Canada during COVID-19, do not withstand scrutiny. It attends to possible justifications for federalism to demonstrate that the best arguments for federalism do not support provincial control over borders that justify provinces possessing, let alone exercising, unilateral authority to close interprovincial borders to persons residing in other provinces.

Due to a dearth of data, nineteenth century lending to sovereign borrowers was a blind date. We argue this is the reason for collateral pledges found in contemporary lending covenants, which enabled not execution, but the production of reliable fiscal data. Lawyers injected collateral clauses in sovereign debt covenants to permit credible disclosure of hard-to-access tax data. The study foregrounds the importance of big law firms as financial intermediaries and information producers. It also contributes a new view on the role played by contracts in sovereign debt.

Lack of water at limiting levels results in drought stress, which may have an impact on the various stages of a crop's life cycle. Four different genotypes of snapmelon (Cucumis melo L. var. momordica) responded differently to 0, 7 and 21 d of simulated drought stress. Information was collected on a range of morpho-physiological, biochemical and molecular characteristics. Each genotype had longer roots, though BAM-VR-312 had the longest roots overall. As the severity of the drought grew, the net photosynthetic rate (Pn) and stomatal conductance (Gs) dropped. In BAM-VR-312, a smaller decline in relative water content (RWC) was recorded, despite the fact that drought stress caused a significant fall in RWC. BAM-VR-312 had smaller accumulations of electrolyte leakage, hydrogen peroxide, phenol and malondialdehyde, although proline content was greater. A decrease in photosynthetic pigments was noted, though BAM-VR-312 had the least reduction. Antioxidant enzyme activity increased in BAM-VR-312, as evidenced by records of ascorbate peroxidase, catalase, guaiacol peroxidase, glutathione reductase and superoxide dismutase. Similarly, expression level of their respective genes was recorded highest in BAM-VR-312. Overall, the study clearly identified distinct genotype based on morpho-physiological, biochemical and molecular properties under drought stress and revealed that the genotype BAM-VR-312 had more efficient drought tolerance mechanisms than the other genotypes under the drought stress condition.

Antimicrobial resistance (AMR) is a growing One Health crisis that can be impacted by other challenges of sustainable development, such as climate change, but few interventions have been assessed with a systems-wide lens. The objectives of this study were to use a previously defined fuzzy cognitive map (FCM) of the Swedish One Health system to: 1) identify areas in the system to target interventions; and 2) test the potential ability and viability of interventions to reduce AMR under a changing climate. The FCM, based on participatory modelling workshops and literature scan, was used to assess the sustainability of eight interventions under potential climate change conditions. Network metrics were calculated to describe the system structure and identify highly impactful nodes. The network metrics identified high-leverage nodes including alternative productions systems and good farming practices. None of the scenarios evaluated were able to adequately reduce AMR within the system. Overall, fuzzy cognitive mapping provides an innovative way to analyse the AMR system, identify high-leverage interventions, and examine potential impact of interventions using a broader systems lens.

Infertility affects 15% of all couples worldwide and 50% of cases of infertility are solely due to male factors. A decrease in motility in the semen is considered one of the main factors that is directly related to infertility. The use of supplementation to improve the overall sperm quality has become increasingly popular worldwide. The purpose of this study was to evaluate whether sperm motility was affected by the combination of serotonin (5-HT), selenium (Se), zinc (Zn), and vitamins D, and E supplementation. Semen samples were incubated for 75 min at 37°C in medium containing varying concentrations of 5-HT, Se, Zn, vitamin D, and E. 5-HT (200 μM), Se (2 μg/ml), Zn (10 μg/ml), vitamin D (100 nM), and vitamin E (2 mmol) have also been shown to increase progressive sperm motility. Three different mixtures of supplements were also tested for their combined effects on sperm motility and reactive oxygen species (ROS) production. While the total motility in the control group was 71.96%, this was found to increase to 82.85% in the first mixture. In contrast the average ROS level was 8.97% in the control group and decreased to 4.23% in the first mixture. Inclusion of a supplement cocktail (5-HT, Se, Zn, vitamins D and E) in sperm processing and culture medium could create an overall improvement in sperm motility while decreasing ROS levels during the incubation period. These molecules may enhance the success of assisted reproduction techniques when present in sperm preparation medium.

Is the COVID-19 pandemic truly a pivotal moment in contemporary governance? This question has sparked multifaceted responses and spurred diverse debates and perspectives. On one side of the spectrum, there are those who ardently argue that this pandemic represents an exceedingly rare and profoundly impactful historical juncture, specifically within the domain of law and governance. In contrast, a counterpoint in this debate contends that the pandemic, rather than introducing an entirely new era, has primarily functioned as an amplifier and extension of pre-existing governing paradigms. Additionally, there is a notable contention that the pandemic has invigorated and revitalized social movements with a central focus on challenging established state structures.

We investigate the effects of different guard geometries on the currents to needle-type Langmuir probes. The results are based on particle-in-cell numerical simulations. We show that if the guard length is less than 6–8 Debye lengths there can be a significant effect on the currents to the probe. A guard radius should not be larger than the Debye length, otherwise it can also significantly affect the currents. However, since guard radii are often close to the probe radius, the second condition is usually satisfied.

Design engineering education is increasingly challenge-based, which requires educators to form cohesive student teams capable of delivering desired outcomes while fostering learning and collaboration. An example is an international network in which students from different global universities collaborate. Student teams work on researching the problem space, re-framing their challenge and producing multiple prototypes. The challenge for the teaching teams is to be able to form multiple cohesive teams out of a pre-selected group of highly motivated students. Because of the exclusive nature of this educational program, it is a suitable case study for exploring student design team formation practices. The aim is to identify the methods, tools, theoretical underpinnings, challenges and limitations of student team formation. We interviewed teachers from seven universities about their practices. The interviewees had several years of experience in team building. The interviews were analyzed to contrast practices across universities as well as to the team formation literature. Our findings show that mixed methods that combine self-assessments and observer-assessment methods are the preferred means of forming teams. Our findings also show that current practices have evolved over time through trial and error, and are only partially grounded in different literatures and not necessarily in team formation literature.

La pandémie de COVID-19 représente-t-elle véritablement un moment charnière pour la gouvernance contemporaine? Cette question suscite de multiples réponses de même qu’une grande variété de débats et de perspectives. D’un côté se trouvent ceux qui soutiennent ardemment que cette pandémie constitue un événement historique des plus rares, aux répercussions profondes, notamment dans le domaine du droit et de la gouvernance. En revanche, d’autres prétendent que la pandémie, plutôt que de marquer le début d’une ère nouvelle, a principalement amplifié et prolongé les paradigmes préexistants de la gouvernance. Par ailleurs, d’aucuns affirment que la pandémie a revigoré et revitalisé les mouvements sociaux axés sur la remise en question des structures étatiques établies.

We propose a new method for identifying active galactic nuclei (AGN) in low mass ($\mathrm{M}_*\leq10^{10}\mathrm{M}_\odot$) galaxies. This method relies on spectral energy distribution (SED) fitting to identify galaxies whose radio flux density has an excess over that expected from star formation alone. Combining data in the Galaxy and Mass Assembly (GAMA) G23 region from GAMA, Evolutionary Map of the Universe (EMU) early science observations, and Wide-field Infrared Survey Explorer (WISE), we compare this technique with a selection of different AGN diagnostics to explore the similarities and differences in AGN classification. We find that diagnostics based on optical and near-infrared criteria (the standard BPT diagram, the WISE colour criterion, and the mass-excitation, or MEx diagram) tend to favour detection of AGN in high mass, high luminosity systems, while the “ProSpect” SED fitting tool can identify AGN efficiently in low mass systems. We investigate an explanation for this result in the context of proportionally lower mass black holes in lower mass galaxies compared to higher mass galaxies and differing proportions of emission from AGN and star formation dominating the light at optical and infrared wavelengths as a function of galaxy stellar mass. We conclude that SED-derived AGN classification is an efficient approach to identify low mass hosts with low radio luminosity AGN.