Two issues are raised. (1) What is the nature of the drug effect Heyman thinks confers value to drugs? (2) What is the evidence that drug use decreases the value of drugs and of conventional incentives over the long-term? There is considerable evidence for the opposite; a persistent increase in the sensitivity of neural systems that mediate drug value.

When base rates are learned and used in an experiential manner subjects show better base rate use, perhaps because the implicit learning system is engaged. A causal framework in which base rates are relevant might also be necessary. Humans might thus perform better on more ecologically valid tasks, which are likely to contain those three components.

Motor learning can be divided into adaptation and skill learning. The cerebellum plays the major role in adaptation learning, which can be described as context-response linkage. Motor skill learning is development of a new ability such as a sequence of motor actions. Skill learning can occur in patients with cerebellar lesions. Cortical mechanisms play a major role in development of skills, [THACH]

The correspondence view is consistent with a theory of direct remembering that assumes continuity between perception and memory. Two implications of direct remembering for correspondence are suggested. It is assumed that forgetting is exponential, and that remembering at one time is independent of factors influencing remembering at another. Elaboration of the correspondence view in the same terms as perception offers a novel approach to the study of memory.

Koriat & Goldsmith provide an excellent analysis of the flexibility of retrieval processes and how they are situationally dependent. I agree with their emphasis on functional considerations and argue that the traditional laboratory experiment motivates the subject to be accurate. However, I disagree with their strong claim that the quantity–accuracy distinction implies an essential discontinuity between traditional and naturalistic approaches to the study of memory.

This commentary presents a self-assessment inventory that will allow readers to determine their own attitude toward the base rate fallacy and its literature. The inventory is scientifically valid but not Medicare/Medicaid reimbursable.

Heyman proposes that external stimuli can promote a switch from a local to a global frame of reference for evaluating the consequences of behavior and that such a change might be critical to breaking the grip of drag addiction. Could incentive stimuli promote a switch in the opposite direction and thus contribute to relapse in the recovered addict?

Strong stimulation of parallel fibers (PFs) leads to localized calcium influx and a long-term depression (LTD) of PF responses at the site of stimulation. These same stimuli also induce depression at spatially distant synapses to the same cell that is mediated by the diffusible messenger nitric oxide (NO). The demonstration of two distinct forms of LTD provide an explanation for the absence of the NO/cGMP pathway in cultured cells, [CBÉPEL et al.; LINDEN; VINCENT]

Koriat & Goldsmith's distinction between the correspondence and storehouse metaphors is valuable for both memory theory and methodology. It is questionable, however, whether this distinction underlies the heated debate about so called “everyday memory” research. The distinction between experimental and naturalistic methodologies better characterizes this debate. I compare these distinctions and discuss how the methodological distinction, between experimental and naturalistic designs, could give rise to different theoretical approaches.

Koehler's summary and critique of research on the base rate fallacy is cogent and persuasive. However, he may have overstated the case, and his suggestions for future research may be too restrictive. We agree that methodological approaches to this topic should be broadened, but we argue that experimental laboratory research and the Bayesian normative standard are useful and should not be abandoned.

It is argued that large-scale neural network simulations of cerebellar cortex and nuclei, based on realistic compartmental models of me major cell populations, are necessary before the problem of motor learning in the cerebellum can be solved, [HOUK et al.; SIMPSON et al.]

Over the years, many theories have been proposed to account for the aberrant behavior of drug dependent individuals. Heyman posits that the existing theories of drug dependence are inadequate to explain the complex processes inherent in human drug-taking. He proposes that incongruous behaviors that comprise addiction, such as continued drug use in spite of adverse consequences, can be explained by application of the matching law approach. While the matching law theory of addiction explains certain aspects of human behavior, its application to the area of addiction must be subjected to experimental verification.

Melioration is not superior and may be inferior to other extensions of behavioral choice theory to addiction studies. Progress in the addiction field will be accelerated by the demise of the disease model rather than by attempting to resolve the contradictions it has created.

Houk et al. suggest that excitatory output from the cerebellar nuclei is fed back into the cerebellum, thus generating a prolonged activity in the cerebellar nuclei which is then molded by inhibitory Purkinje cells. Recent evidence, however, shows that a temporary break in this loop causes a pause in a conditioned eyeblink response, but does not terminate it. [HOUK et al.]

(1) The miscitations of seminal experiments in the base rate literature adds to the existing database of systematic miscitations of wellknown psychological experiments. These miscitations may be caused by a process of reconstructive remembering. (2) Representative design should be the methodological core of Koehler's call for ecologically valid research. This approach can benefit both basic and applied research.

Our response to the commentators covers four general issues: (1) How useful is our proposed conceptualization of the real-life/laboratory controversy in terms of the contrast between the correspondence and storehouse metaphors? (2) What is the relationship between these two metaphors? (3) What are the unique implications of the correspondence metaphor for memory assessment and theory? (4) What are the nature and role of memory metaphors in memory research? We stress that the correspondence metaphor can be usefully exploited independent of the real-life/laboratory controversy, but that a variety of other metaphors, including the storehouse, should also be utilized in order to more fully capture the myriad facets and functions of memory in everyday life.

Heyman's target article contributes to our understanding of addictions by offering solutions to several paradoxes and by recognizing the stable nature of addictive behavior. Previous classical and operant conditioning models have emphasized molecular processes, such as acquisition and extinction, and have failed to address the aggregate effects of long-term exposure to the contingencies of drug and alcohol use.

Recent studies have demonstrated that a Purkinje cell specific ionotropic glutamate receptor δ2 subunit is involved in long-term depression (LTD). Identification of molecules involved in LTD has led to the production of mutant mice defective in LTD, motor control, and motor learning. There are disagreements about whether or not and how nitric oxide (NO) is involved in LTD. [CRÉPEL et al.; LINDEN; VINCENT]

The principles of sexual selection were used as an organizing framework for interpreting cross-national patterns of sex differences in mathematical abilities. Cross-national studies suggest that there are no sex differences in biologically primary mathematical abilities, that is, for those mathematical abilities that are found in all cultures as well as in nonhuman primates, and show moderate heritability estimates. Sex differences in several biologically secondary mathematical domains (i.e., those that emerge primarily in school) are found throughout the industrialized world. In particular, males consistently outperform females in the solving of mathematical word problems and geometry. Sexual selection and any associated proximate mechanisms (e.g., sex hormones) influence these sex differences in mathematical performance indirectly. First, sexual selection resulted in greater elaboration in males than in females of the neurocognitive systems that support navigation in three-dimensional space. Knowledge implicit in these systems reflects an understanding of basic Euclidean geometry, and may thus be one source of the male advantage in geometry. Males also use more readily than females these spatial systems in problem-solving situations, which provides them with an advantage in solving word problems and geometry. In addition, sex differences in social styles and interests, which also appear to be related in part to sexual selection, result in sex differences in engagement iii mathematics-related activities, thus further increasing the male advantage in certain mathematical domains. A model that integrates these biological influences with sociocultural influences on the sex differences in mathematical performance is presented in this article.

Base rates have no necessary relation to judgments that are not themselves probabilities. There is no logical imperative, for instance, that behavioral base rates must affect causal attributions or that base rate information should affect judgments of legal liability. Decision theorists should be cautious in arguing that base rates place normative constraints on judgments of anything other than posterior probabilities.