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Depression and Medierranean diet: analysis of the PREDIDEP randomised trial
- B. M. Cabrera Suárez, A. Sánchez Villegas, J. L. Hernández Fleta, P. Molero Santos, J. T. R. Sosa
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- Journal:
- European Psychiatry / Volume 67 / Issue S1 / April 2024
- Published online by Cambridge University Press:
- 27 August 2024, p. S190
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Introduction
Unipolar depression is a growing global Public Health challenge. During last years, life factors such as diet, have been identified as a target for the development of adjunctive treatment that could reduce the rates of depression. The Mediterranean Diet (MD) is one of the most studied dietary factors that has been inversely associated with depression (Rahe et al. Eur J Nutr. 2014;53:997–1013). The PREDIDEP study is an ongoing secondary prevention trial aimed at assessing the effect of a MD enriched with extra virgin olive oil (EVOO) on depression recurrence (Sánchez-Villegas et al. BMC Psychiatry. 2019 Feb 11;19(1):63).
ObjectivesThis study aims to assess the effectiveness of a remote Mediterranean diet–based nutritional intervention in the context of a trial of depression.
MethodsThe PREDIDEP study is a 2-year multicenter, randomized, single-blinded trial designed to analyse the effect of the MD enriched with extra virgin olive oil (EVOO) on the prevention of depression recurrence. The inervention group received phone contacts with dietist and had access to web-based information, and the control group had usual care for depressed patients. The 14-item MD Adherence Screener (MEDAS) questionnaire and a semiquantitative food frequency questionnaire (FFQ) were collected by dietitians at baseline and at 1-year and 2-year of follow-up. We used mixed effects linear models to assess changes in nutritional variables according to the group of intervention. The trial was registered at ClinicalTrials.gov NCT03081065.
ResultsWe observed that participants in the MD group increased their adherence to MD (between-group difference: 2.50; 95% CI 1.88-3.12; p<0.001) after one and two years (between-group difference: 2.57; 95% CI 1.93-3.22; p<0.001) of intervention compared with control group.
MEDAS questionnaire Control, mean (95% CI) Intervention, mean (95% CI) Between group difference, mean (95% CI) P value Baseline 6.96 (6.54-7.39) 7 (6.63-7.39) N/A N/A 1 year 7.2 (6.82-7.58) 9.74 (9.3-10.18) N/A N/A 1-year change 0.23 (-0.19-0.65) 2.74 (2.28-3.19) 2.50 (1.88-3.12) <0.001 2 years 7.06 (6.66-7.46) 9.68 (9.28-10.07) N/A N/A 2-years change 0.10 (-0.38-0.58) 2.67 (2.24-3.1) 2.57 (1.93-3.22) <0.001 Calculated using mixed-effect models with center as random factor.
P value between group intervention difference.
N/A: not applicable.
MEDAS: Mediterranean Diet Adherence Screener
ConclusionsWe found that this multifaceted remote nutritional intervention is a useful tool kit to maintain the quality of the diet according to the goals of the MD among patients at risk of depression.
Disclosure of InterestNone Declared
Contributors
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- Edited by Robert Audi, University of Notre Dame, Indiana
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- The Cambridge Dictionary of Philosophy
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- 05 August 2015
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- 27 April 2015, pp ix-xxx
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Trypanosoma cruzi Discrete Typing Units in Chagas disease patients from endemic and non-endemic regions of Argentina
- C. I. CURA, R. H. LUCERO, M. BISIO, E. OSHIRO, L. B. FORMICHELLI, J. M. BURGOS, S. LEJONA, B. L. BRUSÉS, D. O. HERNÁNDEZ, G. V. SEVERINI, E. VELAZQUEZ, T. DUFFY, E. ANCHART, R. LATTES, J. ALTCHEH, H. FREILIJ, M. DIEZ, C. NAGEL, C. VIGLIANO, L. FAVALORO, R. R. FAVALORO, D. E. MERINO, S. SOSA-ESTANI, A. G. SCHIJMAN
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- Parasitology / Volume 139 / Issue 4 / April 2012
- Published online by Cambridge University Press:
- 06 February 2012, pp. 516-521
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Genetic diversity of Trypanosoma cruzi may play a role in pathogenesis of Chagas disease forms. Natural populations are classified into 6 Discrete Typing Units (DTUs) Tc I-VI with taxonomical status. This study aimed to identify T. cruzi DTUs in bloodstream and tissue samples of Argentinean patients with Chagas disease. PCR-based strategies allowed DTU identification in 256 clinical samples from 239 Argentinean patients. Tc V prevailed in blood from both asymptomatic and symptomatic cases and Tc I was more frequent in bloodstream, cardiac tissues and chagoma samples from immunosuppressed patients. Tc II and VI were identified in a minority of cases, while Tc III and Tc IV were not detected in the studied population. Interestingly, Tc I and Tc II/VI sequences were amplified from the same skin biopsy slice from a kidney transplant patient suffering Chagas disease reactivation. Further data also revealed the occurrence of mixed DTU populations in the human chronic infection. In conclusion, our findings provide evidence of the complexity of the dynamics of T. cruzi diversity in the natural history of human Chagas disease and allege the pathogenic role of DTUs I, II, V and VI in the studied population.