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Neurotropic enteroviruses co-opt “fair-weather-friend” commensal gut microbiota to drive host infection and central nervous system disturbances

Published online by Cambridge University Press:  15 July 2019

Kevin B. Clark
Kevin B. Clark*
Affiliation:
Research and Development Service, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073; Felidae Conservation Fund, Mill Valley, CA 94941; Campus Champions, Extreme Science and Engineering Discovery Environment (XSEDE), National Center for Supercomputing Applications, University of Illinois at Urbana-Champaign, Urbana, IL 61801; Expert Network, Penn Center for Innovation, University of Pennsylvania, Philadelphia, PA 19104 ; Virus Focus Group, NASA Astrobiology Institute, NASA Ames Research Center, Moffett Field, CA 94035. [email protected]/pub/kevin-clark/58/67/19a
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Abstract

Some neurotropic enteroviruses hijack Trojan horse/raft commensal gut bacteria to render devastating biomimicking cryptic attacks on human/animal hosts. Such virus-microbe interactions manipulate hosts’ gut-brain axes with accompanying infection-cycle-optimizing central nervous system (CNS) disturbances, including severe neurodevelopmental, neuromotor, and neuropsychiatric conditions. Co-opted bacteria thus indirectly influence host health, development, behavior, and mind as possible “fair-weather-friend” symbionts, switching from commensal to context-dependent pathogen-like strategies benefiting gut-bacteria fitness.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 42 , 2019 , e68
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Copyright
Copyright © Cambridge University Press 2019 

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