Under the umbrella concepts of upscaling and emerging technology, a wide variety of phenomena related to technology development and deployment in society are examined to meet societal imperatives (e.g., environment, safety, social justice). The design literature does not provide an explicit common theoretical and practical framework to clarify the assessment method to handle “an” upscaling. In this nebulous context, designers are struggling to identify the characteristics to anticipate the consequences of emerging technology upscaling. This article therefore first proposes a structuring framework to analyze the literature in a wide range of industrial sectors (energy, chemistry, building, etc.). This characterization brought to light five prevalent archetypes clarifying the concepts of upscaling and emerging technology. Then, a synthesis of invariants and methodological requirements for designers is proposed to deal with upscaling assessment according to each archetype, based on a literature review of existing design methods. This literature review process showed a disparity in treatment for some archetypes, regarding the industrial sector. A discussion is consequently proposed in the conclusion to guide design practices.