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28 results

Page 1 of 2

  • Evaluation of the SsIR/NIE recombinant antigen ELISA for the follow up of patients infected by Strongyloides stercoralis: a diagnostic study

  • Marco Prato, Francesca Tamarozzi, Stefano Tais, Eleonora Rizzi, Cristina Mazzi, Dora Buonfrate
  • Journal:
    Parasitology / Volume 151 / Issue 3 / March 2024
    Published online by Cambridge University Press:
    08 January 2024, pp. 295-299
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  • Some serology assays demonstrated useful for post-treatment monitoring of Strongyloides stercoralis infection. Serology frequently has low specificity, which might be improved by the use of recombinant antigens. The Strongy Detect ELISA is based on 2 recombinant antigens (SsIR and NIE) and proved good accuracy. Aim of this study was to evaluate the performance of this test for the post-treatment monitoring of strongyloidiasis. We tested 38 paired sera, with matched fecal tests results, stored in our biobank and originating from a randomized controlled trial. At baseline, all patients tested positive for at least 1 fecal assay among PCR, direct stool microscopy and agar plate culture. Patients were re-tested with both serology and fecal assays 12 months after treatment. Primary outcome was the relative reduction in optical density (OD) between baseline and follow up. We observed that about 95% samples showed a reduction between pre and post-treatment OD, with a median relative reduction of 93.9% (IQR 77.3%–98.1%). In conclusion, the test proved reliable for post-treatment monitoring. However, some technical issues, including that the threshold for positivity has not be predefined, and that a substantial number of samples showed overflow signals, need to be fixed to permit use in routine practice.

  • Parents’ mental health literacy, preferred school counsellor roles, and intention to follow up referrals

  • Monica L. G. M. Bignold, Donnah Anderson
  • Journal:
    Journal of Psychologists and Counsellors in Schools / Volume 33 / Issue 1 / June 2023
    Published online by Cambridge University Press:
    06 March 2023, pp. 90-101
    Print publication:
    June 2023
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  • Many mental illnesses have onset during adolescence, and if untreated may have long-term negative outcomes. Parents and school counsellors can assist adolescents by monitoring for mental illness and facilitating appropriate support. The present study investigated parents’ mental health literacy (MHL), preferred views of school counsellor roles, and intention to follow up referrals. Eighty-seven Australian parents of current secondary school students were recruited to an online cross-sectional survey via convenience sampling. Results showed that, on average, parents had good MHL, moderately endorsed school counsellor roles, and were committed to following up referrals. Higher MHL, but not preferred school counsellor roles, predicted intention to follow up referrals to general practitioners and specialised mental health services. Findings support targeted psychoeducational intervention for parents regarding MHL and the role of the school counsellor and directions for future research are discussed.

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