Using a simple ionic model, the energy necessary to expand a layer structure by a certain distance can be calculated. This has been done for a series of 15 structures including hydroxides, 2:1 and 1:1 structures of various types. Plots of energy versus separation distance show three major groups which have common bonding properties. For large separations, the group with the strongest interlayer bonds contains the brittle micas, the hydroxides, and the 1:1 structures. Intermediate bonding structures are the normal micas and the weakest bonds occur in the zero layer charge 2:1 structures. The relative energies needed for a given separation are not constant so that for small separations the zero layer charge structures such as talc and pyrophyllite are more strongly bonded than the normal micas. These groupings correlate very well with the expandability of the structures by water and other substances. It is proposed that this approach to the study of the layer structures will provide a simple theory explaining the expansion properties of layer silicates.

This study presents the background, rationale and method of action of Biovacc-19, a candidate vaccine for corona virus disease 2019 (Covid-19), now in advanced preclinical development, which has already passed the first acute toxicity testing. Unlike conventionally developed vaccines, Biovacc-19’s method of operation is upon nonhuman-like (NHL) epitopes in 21.6% of the composition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)’s spike protein, which displays distinct distributed charge including the presence of a charged furin-like cleavage site. The logic of the design of the vaccine is explained, which starts with empirical analysis of the aetiology of SARS-CoV-2. Mistaken assumptions about SARS-CoV-2’s aetiology risk creating ineffective or actively harmful vaccines, including the risk of antibody-dependent enhancement. Such problems in vaccine design are illustrated from past experience in the human immunodeficiency viruses domain. We propose that the dual effect general method of action of this chimeric virus’s spike, including receptor binding domain, includes membrane components other than the angiotensin-converting enzyme 2 receptor, which explains clinical evidence of its infectivity and pathogenicity. We show the nonreceptor dependent phagocytic general method of action to be specifically related to cumulative charge from insertions placed on the SARS-CoV-2 spike surface in positions to bind efficiently by salt bridge formations; and from blasting the spike we display the NHL epitopes from which Biovacc-19 has been down-selected.

This study compared the correlates of burden for spouse and adult child caregivers at two points in time and assessed whether correlates at T1 predicted burden at T2. The sample consisted of 878 caregivers to older adults throughout British Columbia who were prescribed cholinesterase inhibitors. Burden was measured six months after the older adult was prescribed the medication and one year later (n = 759). Findings suggest that adult children experience more burden than spouses at both T1 and T2 with adult children but not spouses decreasing their burden over time. Correlates of T1 burden explained significant amounts of variance, revealing differential correlates for the two groups and the importance of caregiver characteristics over patient characteristics. Burden at T2 is explained mostly by T2 factors, plus T1 burden, suggesting the importance of relatively immediate factors for direct effects on caregiver burden. Indirect effects operated through T1 burden.

Ternium Siderar has recently installed a commercial sensor that measures the soundoriginated during blowing. A proper analysis of this signal may give valuable informationabout the slopping tendency of the heat. Data from more than 4000 heats were collected andthoroughly analyzed. The influences of the materials charged and of their compositions onthe slag slopping tendency were investigated. Based on these results, an application toevaluate the risk of slopping for given process conditions was developed.

Summary Absence of the arterial duct has been reported in association with tetralogy of Fallot, with pulmonary stenosis or atresia, other complex cyanotic congenital heart diseases, and anomalies of the aortic arch but not, as far as we are aware, with tricuspid atresia. We report the clinical, surgical, and autopsy findings of a patient with tricuspid atresia whose initial clinical course was influenced by the absence of thearterial duct.

We introduce sign-preserving charges on the system of all orthogonally closed subspaces, F(S), of an inner product space S, and we show that it is always bounded on all the finite-dimensional subspaces whenever dim S = ∞. When S is finite-dimensional this is not true. This fact is used for a new completeness criterion showing that S is complete whenever F(S) admits at least one non-zero sign-preserving regular charge. In particular, every such charge is always completely additive.

Interferometry, a technique widely used in physics to study radiation fields, has been applied to the investigation of dowsing. Pairs of horizontal linear components, typically some metres in length and a metre or so apart, and parallel in a vertical plane, produce patterns of lines that can be mapped by dowsing rods. The lines are parallel to each other and to the components, and are equally spaced. The spacing of the lines depends on the length, separation and composition of the components. The existence of the patterns shows that the dowsing field is wave radiation. Since there is no detectable difference between patterns produced by pairs of components made of good electrical conductors such as copper, and those produced by good insulators such as uPVC, it is concluded that the radiation field is not electromagnetic. Furthermore, aluminium and tin behave differently from copper and steel. The spacing of the lines has been found to depend on time of year. It increases rapidly in late April and falls rapidly in late November; in between these times it appears to be relatively stable except for an isolated maximum in early March. It shows a high degree of repeatability from year to year.