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Psychiatry and Psychobiology (2)

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Monitoring of tricyclic antidepressant plasma levels and clinical response: a review of the literature. Part II
I.R. De Oliveira, P.A.S. Do Prado-Lima, B. Samuel-Lajeunesse
Journal:

Psychiatry and Psychobiology / Volume 4 / Issue 2 / 1989

Published online by Cambridge University Press:

28 April 2020, pp. 81-90

Print publication:

1989
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Part II of this paper contains some general considerations on tricyclic antidepressant (TCA) monitoring. Long-term assessment of TCA plasma levels is advised by the few existent studies, although each of these focusses on different aspects. Cardiovascular and central nervous system toxicity is reviewed as well as pharmacokinetics and the importance of protein binding. Some consideration is also given to their use in elderly patients. The authors conclude that although available data support its usefulness in many situations, routine measurement of TCA levels is not warranted.

Monitoring of tricyclic antidepressant plasma levels and clinical response: a review of the literature. Part I.
I.R. De Oliveira, P.A.S. Do Prado-Lima, B. Samuel-Lajeunesse
Journal:

Psychiatry and Psychobiology / Volume 4 / Issue 1 / 1989

Published online by Cambridge University Press:

28 April 2020, pp. 43-60

Print publication:

1989
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Part I of this paper presents a comprehensive review of plasma level monitoring of tricyclic antidepressants (TCAs) and their relationship to clinical response to antidepressant therapy. Imipramine, nortriptyline, amitriptyline, clomipramine and desipramine are the most widely studied TCAs in this regard. Typical therapeutic plasma concentration ranges are suggested for some of these agents, although a consensus is lacking.