Moving from a behavioral-based to a biological-based classification of mental disorders is a crucial step toward a precision-medicine approach in psychiatry. In the last decade, a big effort has been made in order to stratify genetic, immunological, neurobiological, cognitive, and clinical profiles of patients. Making the case of obsessive–compulsive disorder (OCD), a lot have been made in this direction. Indeed, while the Diagnostic and Statistical Manual of Mental Disorders (DSM) diagnosis of OCD aimed to delineate a homogeneous group of patients, it is now clear that OCD is instead an heterogeneous disorders both in terms of neural networks, immunological, genetic, and clinical profiles. In this view, a convergent amount of literature, in the last years, indicated that OCD patients with an early age at onset seem to have a specific clinical and biological profile, suggesting it as a neurodevelopmental disorder. Also, these patients tend to have a worse outcome respect to adult-onset patients and there is growing evidence that early-interventions could potentially improve their prognosis. Therefore, the aim of the present paper is to review the current available genetic, immunological, neurobiological, cognitive, and clinical data in favor of a more biologically precise subtype of OCD: the early-onset subtype. We also briefly resume current available recommendations for the clinical management of this specific population.

The carbon (C) ratios, namely the atomic ratios of C/(C + M), in nano-sized coherent MC precipitates (M = Ti, Nb) with the NaCl-type (B1) structure in ferritic steels, which had been isothermally aged at 580 °C, were investigated using atom probe tomography (APT). Considering the influences of the trajectory aberration, detection loss, and peak overlap, we determined the C ratios to be ~0.40 and ~0.45 for an equivalent volume diameter of 1.5–5 nm and 1–5 nm for the TiC and NbC precipitates, respectively, suggesting that there is a considerable fraction of C vacancies in both nano-sized precipitates. The apparent C ratios show significant scatter with decreasing particle size, while the apparent mean C ratios of very fine TiC particles, smaller than 1.5 nm, decreased with decreasing particle size. With the use of one of the latest APT instruments with a high detection efficiency, the scattering in the apparent C ratios was reduced because the counting statistics were improved; however, the artificial enrichment of C atoms to particular crystallographic directions of ferrite hindered the determination of the C ratio for very fine TiC particles smaller than 1.5 nm.

Le travail collaboratif désigne un mode de travail où de nombreuses personnes collaborent grâce aux technologies de l’information et de la communication. Cette méthode, naturellement collective et collaborative, permet de maximiser la créativité et l’efficience d’un groupe associé à des projets d’envergure même si elles sont très dispersées dans l’espace et le temps . Nous aborderons, dans cette session, les intérêts de ces méthodes dans l’enseignement de la psychiatrie . Les limites de ces méthodes et des pistes de réflexion seront également discutées . Finalement, les projets et les avancées de l’AESP dans ce domaine seront présentés.

Trauma-informed approaches emerged partly in response to research demonstrating that trauma is widespread across society, that it is highly correlated with mental health and that this is a costly public health issue. The fundamental shift in providing support using a trauma-informed approach is to move from thinking ‘What is wrong with you?’ to considering ‘What happened to you?’. This article, authored by trauma survivors and service providers, describes trauma-informed approaches to mental healthcare, why they are needed and how barriers can be overcome so that they can be implemented as an organisational change process. It also describes how past trauma can be understood as the cause of mental distress for many service users, how service users can be retraumatised by ‘trauma-uninformed’ staff and how staff can experience vicariously the service user's trauma and can themselves be traumatised by practices such as restraint and seclusion. Trauma-informed mental healthcare offers opportunities to improve service users' experiences, improve working environments for staff, increase job satisfaction and reduce stress levels by improving the relationships between staff and patients through greater understanding, respect and trust.

This study investigates the synthesis, characterization, and corrosion behavior of AA6063 composites with the inclusion of micron-sized titanium carbide (TiC) particles with different weight percentages. AA6063/TiC particulate composites containing 0, 3, 6, 9, and 12 weight percent of TiC particles were produced by stir casting. The homogeneous dispersion of TiC particles in the AA6063/TiC composites was revealed from the scanning electron microscopy analysis. Energy dispersive X-ray spectroscopy analysis was conducted to ensure the presence of reinforcement particles in the matrix. Mechanical and corrosion properties of the produced composites are evaluated. The addition of TiC particles to the AA6063, the mechanical, electrical, and corrosion properties are initially increased and then decreased. Mechanical and corrosion study shows that the presence of 9 wt% of TiC particles in the matrix improved mechanical properties than other combination of TiC with the matrix material.