Only a limited number of herbicides are available to provide postemergence (POST) control of selective monocot weeds in grain sorghum crops. The herbicides currently labeled for use with grain sorghum have strict use restrictions, low efficacy on johnsongrass, or weed resistance issues. To introduce a new effective herbicide mode of action for monocot control, multiple companies and universities have been developing herbicide-resistant grain sorghum that would allow producers to use herbicides that inhibit either acetolactate synthase (ALS) or acetyl coenzyme A carboxylase (ACCase) for POST monocot control. An experiment was conducted in Fayetteville, AR, in 2020 and 2021, to determine the effectiveness of two ALS-inhibiting herbicides and nine ACCase-inhibiting herbicides on TamArk™ grain sorghum, conventional grain sorghum, and problematic monocot weed species. Grain sorghum and monocot weeds (johnsongrass, broadleaf signalgrass, barnyardgrass, and Texas panicum) were sprayed when TamArk grain sorghum reached the 2- to 3-leaf stage. TamArk grain sorghum was tolerant of all ACCase-inhibiting herbicides tested, exhibiting ≤10% injury at all evaluation timings, except clethodim and sethoxydim, and had no resistance to the ALS-inhibiting herbicides that were evaluated. Additionally, all ACCase inhibitors except diclofop and pinoxaden controlled all monocots tested by >91% at 28 d after application (DAA). Conversely, the two ALS inhibitors, imazamox and nicosulfuron, provided ≤81% control of broadleaf signalgrass 28 DAA but still controlled all other monocots by >95%. TamArk grain sorghum has low sensitivity to multiple ACCase-inhibiting herbicides and thus provides an effective POST option for monocot weed control. In addition, unwanted volunteer TamArk plants can be controlled with cledthodim, sethoxydim, nicosulfuron, or imazamox. Although the ALS-inhibiting herbicides imazamox and nicosulfuron were not useful on TamArk grain sorghum, they are effective options for monocot control on Igrowth™ and Inzen™ grain sorghum crops, respectively.