Located on the northeastern flank of the Popocatépetl volcano in the state of Puebla, Mexico, the Tetimpa region was buried under volcanic ash from two major eruptions: the first, at the beginning of the present era and the second, between A.D. 700 and 850. We review the volcanic and cultural sequences based on 12 radiocarbon dates, and then focus our discussion on the well-preserved house compounds of the occupation destroyed by the first eruption. The village at Tetimpa was abandoned rapidly in the face of disaster, and domestic goods were left in situ, providing us with a unique, almost ethnographic, view of rural life in the Terminal Preclassic. The house compounds follow a highly standardized pattern, consisting of two or three structures set at right angles to one another around a central patio, in a layout similar to that of the three-temple complexes at Teotihuacan. The wattle-and-daub walls of the rooms are built on stone talud-tablero platforms with a central staircase. Small shrines, located at the midpoint of each patio, provide evidence that volcanic activity formed part of the domestic ritual focus.