Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-848d4c4894-sjtt6 Total loading time: 0 Render date: 2024-07-02T18:30:55.409Z Has data issue: false hasContentIssue false

Chapter 7 - Pharmacology of Local Anesthetics

Published online by Cambridge University Press:  24 May 2023

By
Chang H. Park  and
Garrett W. Burnett
Edited by
Alan David Kaye  and
Richard D. Urman
Alan David Kaye
Affiliation:
Louisiana State University School of Medicine
Richard D. Urman
Affiliation:
Brigham and Women’s Hospital, Boston
Get access

Summary

Cocaine, derived from the coca leaf indigenous to South America, was the first drug to be utilized as a topical local anesthetic by Dr. Carl Koller for glaucoma surgery in 1884. Dr. William Stewart Halstead and Dr. Richard John Hall were the first to demonstrate nerve blockade with cocaine for dental surgery later in that same year. Due to the undesirable effects of cocaine, novocaine and subsequent other local anesthetics were developed.

Type
Chapter
Information
Cambridge Handbook of Anesthesiology , pp. 106 - 118
Publisher: Cambridge University Press
Print publication year: 2023

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Further Reading

Clatayud, J, Gonzalez, A. History of the development and evolution of local anesthesia since the coca leaf. Anesthesiology. 2003;98(6):1503–8.Google Scholar
Taylor, A, McLeod, G. Basic pharmacology of local anaesthetics. BJA Educ. 2020;20(4):34–41.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×