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Chapter 29 - Controversy: midstage vs advanced-stage deep-brain stimulation in the management of Parkinson's disease

from Section IV - Clinical Trials in Parkinson's Diease: Lessons, Controversies and Challenges

Published online by Cambridge University Press:  05 March 2016

By
Mallory L. Hacker  and
David Charles
Edited by
Néstor Gálvez-Jiménez ,
Hubert H. Fernandez ,
Alberto J. Espay  and
Susan H. Fox
Néstor Gálvez-Jiménez
Affiliation:
Cleveland Clinic, Florida
Hubert H. Fernandez
Affiliation:
Cleveland Clinic, Ohio
Alberto J. Espay
Affiliation:
University of Cincinnati
Susan H. Fox
Affiliation:
Toronto Western Hospital
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Type
Chapter
Information
Parkinson's Disease
Current and Future Therapeutics and Clinical Trials
 , pp. 313 - 324
Publisher: Cambridge University Press
Print publication year: 2016

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References

Obeso, JA, Rodriguez-Oroz, MC, Chana, P, et al. The evolution and origin of motor complications in Parkinson's disease. Neurology 2000; 55 (Suppl. 4): S13–20; discussion S21–3.Google Scholar
Deuschl, G, Schade-Brittinger, C, Krack, P. A randomized trial of deep-brain stimulation for Parkinson's disease. N Engl J Med 2006; 355: 896–908.Google Scholar
Williams, A, Gill, S, Varma, T, et al. Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trial. Lancet Neurol 2010; 9: 581–91.Google Scholar
Follett, KA, Weaver, FM, Stern, M, et al. Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease. N Engl J Med 2010; 362: 2077–91.Google Scholar
Okun, MS, Gallo, BV, Mandybur, G, et al. Subthalamic deep brain stimulation with a constant-current device in Parkinson's disease: an open-label randomised controlled trial. Lancet Neurol 2012; 11: 140–9.Google Scholar
Odekerken, VJ, van Laar, T, Staal, MJ, et al. Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial. Lancet Neurol 2013; 12: 37–44.CrossRefGoogle ScholarPubMed
Weaver, F, Follett, K, Stern, M, et al. Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: a randomized controlled trial. JAMA 2009; 301: 63–73.CrossRefGoogle ScholarPubMed
Okun, M, Fernandez, H, Wu, S, et al. Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial. Ann Neurol 2009; 65: 586–95.CrossRefGoogle ScholarPubMed
Krack, P, Batir, A, van Blercom, N, et al. Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease. N Engl J Med 2003; 349: 1925–34.Google Scholar
Simonin, C, Tir, M, Devos, D, et al. Reduced levodopa-induced complications after 5 years of subthalamic stimulation in Parkinson's disease: a second honeymoon. J Neurol 2009; 256: 1736–41.CrossRefGoogle ScholarPubMed
Schüpbach, WM, Maltête, D, Houeto, JL, et al. Neurosurgery at an earlier stage of Parkinson disease: a randomized, controlled trial. Neurology 2007; 68: 267–71.Google Scholar
Charles, PD, Padaliya, BB, Newman, WJ, et al. Deep brain stimulation of the subthalamic nucleus reduces antiparkinsonian medication costs. Parkinsonism Relat Disord 2004; 10: 475–9.Google Scholar
Weaver, FM, Stroupe, KT, Cao, L, et al. Parkinson's disease medication use and costs following deep brain stimulation. Mov Disord 2012; 27: 1398–403.Google Scholar
Schuepbach, WM, Rau, J, Knudsen, K, et al. Neurostimulation for Parkinson's disease with early motor complications. N Engl J Med 2013; 368: 610–22.CrossRefGoogle ScholarPubMed
Dumitriu, A, Popescu, BO. Placebo effects in neurological diseases. J Med Life 2010; 3: 114–21.Google Scholar
Paradis, C. Bias in surgical research. Ann Surg 2008; 248: 180–8.Google Scholar
Charles, PD, Konrad, PE, Davis, TL, et al. Subthalamic nucleus deep brain stimulation in early stage Parkinson's disease. Parkinsonism Relat Disord 2014; 20: 731–7.Google Scholar
Twelves, D, Perkins, KSM, Counsell, C. Systematic review of incidence studies of Parkinson's disease. Mov Disord 2003; 18: 19–31.Google Scholar
Bronstein, JM, Tagliati, M, Alterman, RL, et al. Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues. Arch Neurol 2011; 68: 165.Google Scholar
Shih, LC, Tarsy, D. Deep brain stimulation for the treatment of atypical parkinsonism. Mov Disord 2007; 22: 2149–55.Google Scholar
Lang, AE, Houeto, J, Krack, P, et al. Deep brain stimulation: preoperative issues. Mov Disord 2006; 21 (Suppl. 14): S171–96.Google Scholar
Okun, MS, Rodriguez, RL, Mikos, A, et al. Deep brain stimulation and the role of the neuropsychologist. Clin Neuropsychol 2007; 21: 162–89.Google Scholar
Anheim, M, Fraix, V, Chabardès, S, et al. Lifetime of Itrel II pulse generators for subthalamic nucleus stimulation in Parkinson's disease. Mov Disord 2007; 22: 2436–9.Google Scholar
Funkiewiez, A. Long term effects of bilateral subthalamic nucleus stimulation on cognitive function, mood, and behaviour in Parkinson's disease. J Neurol Neurosurg Psychiatry 2004; 75: 834–9.Google Scholar
Parsons, TD, Rogers, SA, Braaten, AJ, Woods, SP, Tröster, AI. Cognitive sequelae of subthalamic nucleus deep brain stimulation in Parkinson's disease: a meta-analysis. Lancet Neurol 2006; 5: 578–88.CrossRefGoogle ScholarPubMed
Rieu, I, Derost, P, Ulla, M, et al. Body weight gain and deep brain stimulation. J Neurolog Sci 2011; 310: 267–70.Google Scholar
Voon, V, Kubu, C, Krack, P, Houeto, J, Tröster, AI. Deep brain stimulation: neuropsychological and neuropsychiatric issues. Mov Disord 2006; 21 (Suppl. 14): S305–27.Google Scholar
Voon, V, Krack, P, Lang, AE, et al. A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's disease. Brain 2008; 131: 2720–8.CrossRefGoogle ScholarPubMed
Kleiner-Fisman, G, Herzog, J, Fisman, D, et al. Subthalamic nucleus deep brain stimulation: summary and meta-analysis of outcomes. Mov Disord 2006; 21 (Suppl. 14): S290–304.CrossRefGoogle ScholarPubMed
Appel-Cresswell, S, La Fuente-Fernandez de, R, Galley, S, McKeown, MJ. Imaging of compensatory mechanisms in Parkinson’s disease. Curr Opin Neurol 2010; 23: 407–12.Google Scholar
Rodriguez-Oroz, MC. Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up. Brain 2005; 128: 2240–9.Google Scholar
Wider, C, Pollo, C, Bloch, J, Burkhard, PR, Vingerhoets, FJG. Long-term outcome of 50 consecutive Parkinson's disease patients treated with subthalamic deep brain stimulation. Parkinsonism Relat Disord 2008; 14: 114–19.Google Scholar
Zibetti, M, Merola, A, Rizzi, L,et al. Beyond nine years of continuous subthalamic nucleus deep brain stimulation in Parkinson's disease. Mov Disord 2011; 26: 2327–34.Google Scholar
Hilker, R, Portman, A, Voges, J, Staal, M. Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulation. J Neurol 2005; 76: 1217–21.Google Scholar
Maesawa, S, Kaneoke, Y, Kajita, Y, et al. Long-term stimulation of the subthalamic nucleus in hemiparkinsonian rats: neuroprotection of dopaminergic neurons. J Neurosurg 2004; 100: 679–87.Google Scholar
Temel, Y, Visser-Vandewalle, V, Kaplan, S, et al. Protection of nigral cell death by bilateral subthalamic nucleus stimulation. Brain Res 2006; 1120: 100–5.Google Scholar
Harnack, D, Meissner, W, Jira, J, et al. Placebo-controlled chronic high-frequency stimulation of the subthalamic nucleus preserves dopaminergic nigral neurons in a rat model of progressive Parkinsonism. Exp Neurol 2008; 210: 257–60.Google Scholar
Wallace, BA, Ashkan, K, Heise, CE, et al. Survival of midbrain dopaminergic cells after lesion or deep brain stimulation of the subthalamic nucleus in MPTP-treated monkeys. Brain 2007; 130: 2129–45.Google Scholar
Spieles-Engemann, AL, Behbehani, MM, Collier, TJ, et al. Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss. Neurobiol Dis 2010; 39: 105–15.Google Scholar
Olanow, CW, Kieburtz, K, Schapira, AH. Why have we failed to achieve neuroprotection in Parkinson's disease? Ann Neurol 2008; 64(Supp. 2): S101–10.Google Scholar
Moro, E, Lozano, A, Pollak, P, et al. Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease. Mov Disord 2010; 25: 578–86.Google Scholar
Castrioto, A, Lozano, A, Poon, Y, et al. Ten-year outcome of subthalamic stimulation in Parkinson disease: a blinded evaluation. Arch Neurol 2011; 68: 1550–6.Google Scholar
Ngoga, D, Mitchell, R, Kausar, J, et al. Deep brain stimulation improves survival in severe Parkinson's disease. J Neurol Neurosurg Psychiatry 2013; 85: 17–22.Google Scholar
Aarsland, D, Marsh, L, Schrag, A. Neuropsychiatric symptoms in Parkinson's disease. Mov Disord 2009; 24: 2175–86.Google Scholar
Welter, ML, Houeto, JL, Tezenas du Montcel, S, et al. Clinical predictive factors of subthalamic stimulation in Parkinson's disease. Brain 2002; 125: 575–83.Google Scholar
Rodriguez-Oroz, MC, Moro, E, Krack, P. Long-term outcomes of surgical therapies for Parkinson's disease. Mov Disord 2012; 27: 1718–28.Google Scholar
Schermer, M. Ethical issues in deep brain stimulation. Front Integr Neurosci 2011; 5: 17.Google Scholar
Bell, E, Bell, E, Maxwell, B, et al. Deep brain stimulation and ethics: perspectives from a multisite qualitative study of Canadian neurosurgical centers. World Neurosurg 2011; 76: 537–47.Google Scholar
Ardouin, C, Pillon, B, Peiffer, E, et al. Bilateral subthalamic or pallidal stimulation for Parkinson's disease affects neither memory nor executive functions: a consecutive series of 62 patients. Ann Neurol 1999; 46: 217–23.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
Massano, J, Garrett, C. Deep brain stimulation and cognitive decline in Parkinson's disease: a clinical review. Front Neurol 2012; 3: 66.Google Scholar
Weintraub, D, Duda, JE, Carlson, K, et al. Suicide ideation and behaviours after STN and GPi DBS surgery for Parkinson's disease: results from a randomised, controlled trial. J Neurol Neurosurg Psychiatry 2013; 84: 1113–18.Google Scholar
Meissner, W, Schreiter, D, Volkmann, J, et al. Deep brain stimulation in late stage Parkinson's disease: a retrospective cost analysis in Germany. J Neurol 2005; 252: 218–23.Google Scholar
Oyama, G, Okun, MS, Schmidt, P, et al. Deep brain stimulation may improve quality of life in people with Parkinson's disease without affecting caregiver burden. Neuromodulation 2013; 17: 126–32.Google Scholar
Temel, Y, Kessels, A, Tan, S, et al. Behavioural changes after bilateral subthalamic stimulation in advanced Parkinson disease: a systematic review. Parkinsonism Relat Disord 2006; 12: 265–72.Google Scholar
Kopin, IJ. MPTP: an industrial chemical and contaminant of illicit narcotics stimulates a new era in research on Parkinson's disease. Environ Health Perspect 1987; 75: 45–51.Google Scholar
Schwarting, RK, Huston, JP. The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments. Prog Neurobiol 1996; 50: 275–331.CrossRefGoogle ScholarPubMed
Deep-Brain Stimulation for Parkinson's Disease Study Group. Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease. N Engl J Med 2001; 345: 956–63.Google Scholar
Luquin, M, Saldise, L, Guillén, J, et al. Does increased excitatory drive from the subthalamic nucleus contribute to dopaminergic neuronal death in Parkinson's disease? Exp Neurol 2006; 201: 407–15.Google Scholar
Visser-Vandewalle, V, van der Linden, C, Temel, Y, et al. Long-term effects of bilateral subthalamic nucleus stimulation in advanced Parkinson disease: a four year follow-up study. Parkinsonism Relat Disord 2005; 11: 157–65.Google Scholar
Rodriguez-Oroz, M, Obeso, J, Lang, A, et al. Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up. Brain 2005; 128: 2240–9.Google Scholar
Cheng, H, Ulane, CM, Burke, RE. Clinical progression in Parkinson disease and the neurobiology of axons. Ann Neurol 2010; 67: 715–25.CrossRefGoogle ScholarPubMed
Kordower, JH, Olanow, CW, Dodiya, HB, et al. Disease duration and the integrity of the nigrostriatal system in Parkinson's disease. Brain 2013; 136: 2419–31.Google Scholar
Gill, CE, Allen, LA, Konrad, PE, et al. Deep brain stimulation for early-stage Parkinson's disease: an illustrative case. Neuromodulation 2011; 14: 515–22.Google Scholar
Charles, PD, Dolhun, RM, Gill, CE, et al. Deep brain stimulation in early Parkinson's disease: enrollment experience from a pilot trial. Parkinsonism Relat Disord 2012; 18: 268–73.Google Scholar
Charles, D, Tolleson, C, Davis, T, Gill, C. et al. Pilot study assessing the feasibility of applying bilateral subthalamic nucleus deep brain stimulation in very early stage Parkinson's disease: study design and rationale. J Parkinson's Dis 2012; 2: 215–23.Google Scholar
Kahn, E, D'Haese, P-, Dawant, B, et al. Deep brain stimulation in early stage Parkinson's disease: operative experience from a prospective randomised clinical trial. J Neurol Neurosurg Psychiatry 2012; 83: 164–70.Google Scholar
Tramontana, MG, Molinari, AL, Konrad, PE, et al. Neuropsychological effects of deep brain stimulation in early stage Parkinson's disease. J Parkinsons Dis 2015; 5: 151–63.Google Scholar
Hacker, ML, Tonascia, J, Turchan, M, et al. Deep brain stimulation may reduce the relative risk of clinically important worsening in early stage Parkinson's disease. Parkinsonism Relat Disord 2015; 21: 1177–83.Google Scholar
Finder, SG, Bliton, MJ, Gill, CE, Davis, TL, Konrad, PE, Charles, PD. Potential subjects' responses to an ethics questionnaire in a phase I study of deep brain stimulation in early Parkinson's disease. J Clin Ethics 2012; 23: 207–16.Google Scholar
Finder, SG, Bliton, MJ. Fortitude and Community: Response to Yee and Ford. J. Clin Ethics 2012; 23: 221–3.Google Scholar
Charles, D, Konrad, PE, Davis, TL, Neimat, JS, Hacker, ML, Finder, SG. Deep brain stimulation in early stage Parkinson's disease. Parkinsonism Relat Disord 2015; 21: 347–8.Google Scholar
Hacker, M, Charles, D, Finder, S. Deep brain stimulation in early stage Parkinson's disease may reduce the relative risk of symptom worsening. Parkinsonism Related Disord 2016; 22: 112–13.Google Scholar

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