Looking closely at significant changes in both fields – epidemiology and performance –the chapter attempts to disentangle their already naturalized interrelation in order to show their actual reciprocal relation in a new light of today’s socio-cultural context. It starts with a close reading of a recently published outbreak novel, Emily St. John Mandel’s ’Station Eleven’ (2014) which thematizes theatre as an art and way of life, albeit putting contagion and performance apart. Premised on that, the chapter demonstrates that the historically distinct epidemiological conceptualization of viruses which once inspired Artaud’s ’The Theatre and the Plague’ (1933) has little to do with the actual syndemic imaginary of viral diseases. In turn, this imaginary is employed here as a perspective from which to perceive and understand divergent performativity of today’s public space. Because it is public space where the critical entanglement of performance and contagion could be effectively spotlighted nowadays.