Debiasing procedures are experimental methods aimed at correcting errors arising from the cognitive biases of the experimenter. We discuss two of these methods, the predesignation rule and randomization, showing to what extent they are open to the experimenter’s regress: there is no metarule to prove that, after implementing the procedure, the experimental data are actually free from biases. We claim that, from a contractarian perspective, these procedures are nonetheless defensible since they provide a warrant of the impartiality of the experiment: we only need proof that the result has not been intentionally manipulated for prima facie acceptance.

Several authors, e.g. Patrick Suppes and I. J. Good, have recently argued that the paradox of confirmation can be resolved within the developing subjective Bayesian account of inductive reasoning. The aim of this paper is to show that the paradox can also be resolved by the rival orthodox account of hypothesis testing currently employed by most statisticians and scientists. The key to the orthodox statistical resolution is the rejection of a generalized version of Hempel's instantiation condition, namely, the condition that a PQ is inductively relevant to the hypothesis (x)(Px ⊃ Qx) even in the absence of all further information. Though their reasons differ, it turns out that Bayesian and orthodox statisticians agree that this condition lies at the heart of the paradox.

Caenorhabditis elegans (C. elegans) is a tiny worm that has become the focus of a large number of worldwide research projects examining its genetics, development, neuroscience, and behavior. Recently several groups of investigators have begun to tie together the behavior of the organism and the underlying genes, neural circuits, and molecular processes implemented in those circuits. Behavior is quintessentially organismal—it is the organism as a whole that moves and mates—but the explanations are devised at the molecular and neurocircuit levels, and tested in populations using protocols that span many levels of aggregation. Following a brief review of the main relevant features of C. elegans, I describe some of these circuits, and then discuss two contrasting approaches in behavioral genetics and neural network analysis of the worm. Finally, I outline the rudiments of a “field and focus” explanation model using the two contrasting approaches.

Those—other social scientists as well as laymen—who have read recent studies of national character and culture by anthropologists, while not having had experience in this field themselves, often seem to believe that the results which such anthropological investigators obtain are interesting, but that the methods used were intuitional, magical, or just invisible. The status of the work is cast in doubt, as falling short of an ideal that scientific description and analysis must be reproducible by any observer to whom a set of techniques of the discipline has been communicated. This paper attempts to show why and how such a belief is erroneous, and then to describe some of the fundamentals of method in current cultural anthropology as used in research and as related to the general structure of scientific method today.

Color constancy is a foundational and yet puzzling phenomenon. Standard appearance invariantism is threatened by the psychophysical matching argument, which is taken to favor variantism. This argument, however, is inconclusive. The data at best support a pluralist view: color constancy is sometimes variantist, sometimes invariantist. I add another potential explanation of these data, complex invariantism, which adopts an atypical six-dimensional model of color appearance. Finally, I prospect for a unifying conception of constancy among two neglected notions: discriminatory color constancy and relational color constancy. The former arguably marks a common core capacity that is present across widely differing viewing contexts.

I argue that all current research programs in quantum gravity conform to the 17th century hypothetico-deductive model of scientific inquiry, perhaps of necessity given the current state of technology. In so far as they do not recognize and advertise the shortcomings of the research method they use, they do a disservice to the integrity of science, for the method admits of far less certainty accruing to its products than one would be led to believe by the pronouncements of researchers in the area.

Paul Churchland has recently argued that empirical evidence strongly suggests that perception is penetrable to the beliefs or theories held by individual perceivers (1988). While there has been much discussion of the sorts of psychological cases he presents, little has been said about his arguments from neurology. I offer a critical examination of his claim that certain efferents in the brain are evidence against perceptual encapsulation. I argue that his neurological evidence is inadequate to his philosophical goals, both by itself and taken in concert with his psychological evidence.

GRW models of the physical world are criticized in the literature for involving wave function “tails” that allegedly create fatal interpretive problems and even compromise standard arithmetic. I find such objections both unfair and misguided. But not all is well with the GRW approach. One complaint I articulate in this paper does not have to do with tails as such but with the specific way in which past physical structures linger forever in the total GRW wave function. By pushing the total proposal towards either the “Many Worlds” approach or the Bohmian approach, this feature diminishes extant GRW claims to preferability. I suggest, however, that the problem here is just an artifact of the particular and ultimately optional genre of collapse mechanism chosen by GRW.

In a recent note ([3]) Roger Carlson presented a rather negative appraisal of my treatment of the logic of Fisherian significance testing in [10]. The main issue between us involves Carlson's thesis that, within the limits set by Fisher, standard significance tests are valuable tools of data analysis as they stand, i.e., without modification of the structure of the reasoning they employ. Call this the adequacy thesis. In my paper I argued that (i) the pattern of reasoning employed by tests of significance needs to be justified in spite of its unquestioned acceptance by most researchers, (ii) The best justification offered to date—by R. A. Fisher—is seriously defective. Therefore (iii) the adequacy thesis is not justified. I proposed some alterations of the pattern of reasoning employed by tests of significance and argued that they guarantee that tests are adequate epistemological tools.

This paper represents an attempt to indicate the idea of a logic slightly more general than sentential calculus, which is applicable to many philosophical issues. In particular, I shall use this generalized calculus to discuss a variation of the logic of imperatives. In part I, certain general considerations about indicative calculi provide the basis, as well as indicate the need, for the more formal construction of part II. Part III illustrates the analytical power of the tool constructed, and tries to show its relevance for philosophy.

Richard Otte (1985) has recently criticized the resolution of Simpson's paradox given by Nancy Cartwright (1979). He argues that there are difficulties with the version of the theory of probabilistic causality that Cartwright has developed, and that there is a way in which Simpson's paradox can arise that Cartwright's theory cannot handle. And Otte develops his own theory of probabilistic causality. I defend Cartwright's solution, and I argue that there are difficulties with the theory of probabilistic causality that Otte proposes.

The first part of the paper distinguishes between a real past which has nothing to do with historical events and an historical past made up of hypothetical events introduced for the purpose of explaining historical evidence. Attention is next paid to those so-called ancillary historical disciplines which study historical evidence, and it is noted that the historical event is brought in to explain the particular constellation of different kinds of historical evidence which are judged to belong together. The problem of explaining events is then taken up, and an attempt is made to defend the view that such explanation must presuppose general laws. And this is followed by a discussion, partly speculative, of social-historical laws. The final section of the paper tries to argue that the subjective intentions of individuals are irrelevant to historical explanation.

Recently, Barbara Renzi argued that Kuhn's account of scientific change is undermined by mismatches in the analogy that Kuhn supposedly draws between scientific change and biological evolution. We argue that Renzi's criticism is inadequate to Kuhn's account of scientific change, as Kuhn does not draw any precise analogy between the mechanisms of scientific change and biological evolution nor aims to argue that the mechanisms of scientific change and biological evolution are similar in any important respects. Therefore, pointing to mismatches between the central concepts that feature in the descriptions of the two phenomena simply misses the point of Kuhn's analogy.

There has been a long-standing and sometimes passionate debate between physicists over whether a dynamical framework for quantum systems should incorporate not completely positive (NCP) maps in addition to completely positive (CP) maps. Despite the reasonableness of the arguments for complete positivity, we argue that NCP maps should be allowed, with a qualification: these should be understood, not as reflecting ‘not completely positive’ evolution, but as linear extensions, to a system’s entire state space, of CP maps that are only partially defined. Beyond the domain of definition of a partial-CP map, we argue, much may be permitted.

Binding specificity is a centrally important concept in molecular biology, yet it has received little philosophical attention. Here I aim to remedy this by analyzing binding specificity as a causal property. I focus on the concept’s role in drug design, where it is highly prized and hence directly studied. From a causal perspective, understanding why binding specificity is a valuable property of drugs contributes to an understanding of causal selection—of how and why scientists distinguish between causes, not just causes from noncauses. In particular, the specificity of drugs is precisely what underwrites their value as experimental interventions on biological processes.

A paradigmatic shift in the foundations of quantum mechanics is recorded, from interpreting to reconstructing quantum theory. Examples of reconstruction are analyzed, and conceptual foundations of the information-theoretic reconstruction developed. A concept of intentionally incomplete reconstruction is introduced to mark the novel content of research in the foundation of quantum theory.

Within the context of general relativity, we consider one definition of a “time machine” proposed by Earman, Smeenk, and Wüthrich. They conjecture that, under their definition, the class of time machine spacetimes is not empty. Here, we prove this conjecture.

Recently, philosophers have sought to determine the nature of individuals relevant to evolution by natural selection or evolutionary individuals. The Evolutionary Contingency Thesis is a claim about evolution that emphasizes the role of contingency or dependency relations and chance-based factors in how evolution unfolds. In this article, I argue that if we take evolutionary contingency seriously, then we should be pluralists about the types of individuals in selection.

Natural conditions are provided that are sufficient to ensure that causality as defined by approaches that use counterfactual dependence and structural equations will be transitive.