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Light-triggered modulation of cell antioxidant defense by polymer semiconducting nanoparticles in a model organism

Published online by Cambridge University Press:  21 June 2018

Maria Moros ,
Anna Lewinska ,
Giada Onorato ,
Maria Rosa Antognazza ,
Francesca Di Maria ,
Martina Blasio ,
Guglielmo Lanzani ,
Angela Tino ,
Maciej Wnuk  and
Claudia Tortiglione Open the ORCID record for Claudia Tortiglione [Opens in a new window]
Maria Moros
Affiliation:
Istituto di Scienze Applicate e Sistemi Intelligenti “E. Caianiello”, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Italy
Anna Lewinska
Affiliation:
Department of Cell Biochemistry, Faculty of Biotechnology, University of Rzeszow, Pigonia 1, 35-310 Rzeszow, Poland
Giada Onorato
Affiliation:
Istituto di Scienze Applicate e Sistemi Intelligenti “E. Caianiello”, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Italy
Maria Rosa Antognazza
Affiliation:
Center for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, Via Pascoli 70/3, 20133 Milano, Italy
Francesca Di Maria
Affiliation:
Istituto per la Sintesi Organica e la Fotoreattivita’, Consiglio Nazionale delle Ricerche, Via P. Gobetti 101, 40129 Bologna, Italy
Martina Blasio
Affiliation:
Istituto di Scienze Applicate e Sistemi Intelligenti “E. Caianiello”, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Italy
Guglielmo Lanzani
Affiliation:
Center for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, Via Pascoli 70/3, 20133 Milano, Italy Department of Physics, Politecnico di Mila, P.zza L. da Vinci 32, 20133 Milano, Italy
Angela Tino
Affiliation:
Istituto di Scienze Applicate e Sistemi Intelligenti “E. Caianiello”, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Italy
Maciej Wnuk
Affiliation:
Department of Genetics, Faculty of Biotechnology, University of Rzeszow, Pigonia 1, 35-310 Rzeszow, Poland
Claudia Tortiglione*
Affiliation:
Istituto di Scienze Applicate e Sistemi Intelligenti “E. Caianiello”, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Italy
*
Address all correspondence to Claudia Tortiglione at [email protected]
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Abstract

Photovoltaic organic semiconductors are emerging in many therapeutic applications, including drug delivery and optical control of cell function. However, for their safe use the possible concomitant elicitation of undesired responses in target cells need to be carefully evaluated. Here we describe molecular responses activated by semiconducting polymer nanoparticles based on poly(3-hexyl)thiophene (P3HT) in the model Hydra vulgaris, previously shown to respond to P3HT-NP photostimulation and showed a decrease in the total antioxidant capacity and an increase in the DNA and protein oxidation levels, paving the way to a novel use of photovoltaic devices to control intracellular redox equilibrium.

Type
Research Letters
Information
MRS Communications , Volume 8 , Issue 3 , September 2018 , pp. 918 - 925
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Copyright
Copyright © Materials Research Society 2018 

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Footnotes

*

These authors contributed equally to this work.

†

Present address: Instituto de Ciencia de Materiales de Aragón, C/Mariano Esquillor s/n, 50018 Zaragoza, Spain.

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