Our aim with this special issue on the future of artificial intelligence (AI) politics, policy, and business is to give space to considering how the balalnce between risk and reward from AI technologies is and perhaps should be pursued by the public and private sectors. Ultimately, private firms and regulators will need to work collaboratively, given the complex networks of actors involved in AI development and deployment and the potential for the technology to alter existing policy regimes. We begin the introduction of this special issue of Business & Politics with a discussion of the growth in AI technology use and discussions of appropriate governance, followed by a consideration of how AI-related politics, policy, and business intersect. We then summarize the contributions of the authors in this issue and conclude with thoughts about how political science, public administration, and public policy scholars have much to offer, as well as much to study, the establishment of effective AI governance.