The advantages and limitations of frequency domain and time domain methods for estimating the interannual variability arising from day-to-day weather events are summarized. A modification of the time domain method is developed and its application in examining a precondition for the frequency domain method is demonstrated. A combined estimation procedure is proposed: it takes advantage of the strengths of both methods. The estimation procedures are tested with sets of synthetic data and are applied to long time series of three meteorological parameters. The impacts of the different methods on tests of potential long-range predictability for seasonal means are also discussed.