A replacement series study was conducted in a greenhouse in 1998 and 1999 to evaluate the interference interactions among two rice cultivars and two red rice ecotypes. Plants were established in proportions of 3:0, 2:1, 1:2, and 0:3 (rice–red rice) plants/pot. Relative yield of Kaybonnet based on the shoot dry weight was lower than that of KatyRR or LA3, whereas PI 312777 was comparable to that of KatyRR and LA3. These results indicate that Kaybonnet was less competitive than PI 312777 when contrasted with KatyRR and LA3 red rice ecotypes. Kaybonnet (commercial rice cultivar) was dominated by both KatyRR (suspected rice × red rice cross) and LA3 (tall red rice ecotype) in tiller production, whereas PI 312777 (weed-suppressive cultivar) was comparable to either KatyRR or LA3. Both KatyRR and LA3 considerably reduced the leaf area of Kaybonnet. In contrast, PI 312777 reduced the growth of KatyRR, and its leaf area was comparable to that of LA3. The data suggest that high tillering capacity, as demonstrated by PI 312777, should be considered when breeding for rice cultivars that are competitive against weeds. This agronomic characteristic of rice may improve the success of reduced herbicide rate application programs.