Adverse childhood experiences (ACEs), including family dysfunction as well as abuse and neglect, have enduring effects on development. Research across diverse populations documents that ACEs are prevalent and cumulative, influencing children’s developing mental, emotional, and physical systems that affect long-term physical and mental health, social relationships, and parenting attitudes and behaviors. Protective and compensatory experiences (PACEs), including nurturing relationships and stable, supportive environments, can mitigate the effects of ACEs, disrupting the intergenerational transmission of adversity. In this chapter, we summarize the effects of ACEs on neurobiological, cognitive, social, and emotional development. Next, we discuss the effects of cumulative protective experiences and the introduce the concept of Balanced Parenting to promote resilience in the face of adversity. We include examples of how parents and other caregivers can effectively parent children with a history of ACEs at different developmental stages, and conclude with a discussion of new directions for research and practice.