As COVID-19 began to spread around the world, so did reports of discrimination and violence against people from marginalized groups. We argue that in a global politics characterized by racialized inequality, pandemics such as COVID-19 exacerbate the marginalization of already oppressed groups. We review published research on previous pandemics to historicize pandemic othering and blame, and enumerate some of the consequences for politics, policy, and public health. Specifically, we draw on lessons from smallpox outbreaks, the third bubonic plague, the 1918 influenza pandemic, and more recent pandemics, such as HIV/AIDS, SARS, and Ebola. We also compile reports to document the discrimination and violence targeting marginalized groups early in the COVID-19 pandemic. This article lays bare the continuation of a long history of othering and blame during disease outbreaks and identifies needs for further inquiry to understand the persistence of these pandemic politics.